Beginner Puzzle (<150): Docking Design

Closed since about 12 years ago

Summary

• Created: July 29, 2013
• Expires: January 16, 2014 at 23:00 UTC
• Max points: 100

Description

We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.



START HERE:

If you are new to Foldit, here are detailed instructions to get you started:

http://fold.it/portal/node/988864

_____________________________

If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :

- try all puzzles not only "Beginners" ones,

- fold first the ones you like the most,

- try it by yourself to understand what works and what doesn't,

- ask for tips in global chat when you think you don't understand something.

Make sure you have followed these tutorials:

- Lonely Sheets,

- Lock and Lower,

- Rebuild,

- Structure and Rebuild,

- Movin' Along,

- Control over Clashing,

- Intro to Design,

- Swappin' Sidechains,

- Mass Mutate,

- Insertion and Deletion

before starting this puzzle.

Top groups

• 31. khalil 1 pt. 10,173
• 32. Adams Genetics 1 1 pt. 10,151
• 33. Adams Genetics 1 pt. 10,151
• 34. Window Group 1 pt. 10,079
• 35. Geekdo 1 pt. 9,025
• 36. Team Aquidneck Island 1 pt. 8,594
• 37. CHM542_Fall2013 1 pt. 8,594

Top soloists

• 51. Molgroth 75 pts. 10,641
• 52. Ewa Zolocinska 75 pts. 10,641
• 53. minimajack 75 pts. 10,640
• 54. jordi_pupu 74 pts. 10,640
• 55. SaLLIa666 74 pts. 10,638
• 56. ponderosa 73 pts. 10,636
• 57. natteruw 73 pts. 10,636
• 58. javatlacati 72 pts. 10,635
• 59. TheBlobCreator 72 pts. 10,635
• 60. Double-Blind 71 pts. 10,634