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894: CASP11 T0763: WeFold Round

Closed since about 12 years ago

Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11

Summary

Created
May 16, 2014
Expires
Max points
100
Description

In this final round for CASP11 Target T0763, we are starting you off with 1 server prediction selected by our WeFold collaborators. Many more details in the puzzle comments.

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Comments

beta_helix Staff Lv 1

Great question, karstenw!

The CASP organizers had already posted this one as a CASP ROLL target last year:
http://predictioncenter.org/casprol/target.cgi?id=88
=
http://predictioncenter.org/casp11/target.cgi?id=8

(Maybe it looked a bit familiar: https://fold.it/portal/node/996451 :-)

but I think it’s such an interesting one that they wanted the human CASP11 groups to take a stab at it.

They already told us that it’s a dimer (which they hadn’t mentioned in CASP ROLL) and check out the trans-membrane prediction:

Because of all of this, our confidence in this server model is quite low, so you should feel free to try very drastic topological changes (rather than just trying to find the top-scoring conformation closest to the starting structure).

spmm Lv 1

Great question, karstenw!

The CASP organizers had already posted this one as a CASP ROLL target last year:
http://predictioncenter.org/casprol/target.cgi?id=88
=
http://predictioncenter.org/casp11/target.cgi?id=8

(Maybe it looked a bit familiar: https://fold.it/portal/node/996451 :-)

but I think it’s such an interesting one that they wanted the human CASP11 groups to take a stab at it.

They already told us that it’s a dimer (which they hadn’t mentioned in CASP ROLL) and check out the trans-membrane prediction:

Because of all of this, our confidence in this server model is quite low, so you should feel free to try very drastic topological changes (rather than just trying to find the top-scoring conformation closest to the starting structure).

bkoep Staff Lv 1

So even if we create a solution with a different topology when we know the native is a dimer, we have little chance of making it score in CASP or foldit unless we get the other part, assuming you can work out what the sym is?

spmm Lv 1

hopefully it is not like 3ks7 which would be a lovely sym puzzle :D

beta_helix Staff Lv 1

In CASP10 we were fortunate to correctly guess the symmetry of one of the refinement targets (TR722), so we were able to post it as a symmetry puzzle: http://fold.it/portal/node/993251#comment-19148

It was this target that our WeFold collaborators were able to pick out and improve one of your Foldit predictions, resulting in the best CASP submission for that target (wfFUIK): http://fold.it/portal/files/Slide2.png

So, if for any CASP11 targets you are find some evidence of symmetry, please do let us know!

But I don't know if everyone would agree that a 397 symmetry puzzle would be lovely :-P
http://www.pdb.org/pdb/explore/explore.do?structureId=3KS7