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898: 75 Residue Monomer Design: Weak Helices

Closed since almost 12 years ago

Intermediate Intermediate

Summary

Created
May 21, 2014
Expires
Max points
100
Description

This is a design puzzle with 75 residues and is very similar to previous design puzzles, except that helices should not score as well as they normally do. Try some new designs and see how they compete with handicapped helices! There are 3 filters enabled on this puzzle: the Residue IE Score monitors that all PHE, TYR, and TRP residues are scoring well; the Core Existence filter checks that at least 30% of the residues are buried in the core of your design; and the Fragment filter scans for parts of your design that are unlikely to fold up naturally. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Deleted group 11. Deleted group pts. 8,393
  2. Avatar for Go Science 12. Go Science 2 pts. 8,363
  3. Avatar for Repro-men 13. Repro-men 1 pt. 8,179
  4. Avatar for Italiani Al Lavoro 14. Italiani Al Lavoro 1 pt. 7,605
  5. Avatar for Mojo Risin' 15. Mojo Risin' 1 pt. 7,439
  6. Avatar for Deleted group 16. Deleted group pts. 7,367
  7. Avatar for Crunching Family 17. Crunching Family 1 pt. 7,271
  8. Avatar for Team Schleswig-Holstein 18. Team Schleswig-Holstein 1 pt. 5,928
  9. Avatar for Piratenpartei Deutschland 19. Piratenpartei Deutschland 1 pt. 2,514
  10. Avatar for HMT heritage 20. HMT heritage 1 pt. 0
  1. Avatar for Deleted player 51. Deleted player 7 pts. 7,872
  2. Avatar for pizpot 52. pizpot Lv 1 6 pts. 7,872
  3. Avatar for jobo0502 53. jobo0502 Lv 1 6 pts. 7,844
  4. Avatar for turbolag 54. turbolag Lv 1 5 pts. 7,830
  5. Avatar for MaartenDesnouck 55. MaartenDesnouck Lv 1 5 pts. 7,767
  6. Avatar for Ashrai 56. Ashrai Lv 1 5 pts. 7,749
  7. Avatar for nemo7731 57. nemo7731 Lv 1 4 pts. 7,632
  8. Avatar for eikem 58. eikem Lv 1 4 pts. 7,610
  9. Avatar for MuckeMcFly 59. MuckeMcFly Lv 1 4 pts. 7,605
  10. Avatar for Tweedle Dumb 60. Tweedle Dumb Lv 1 3 pts. 7,589

Comments

retiredmichael Lv 1

not working, 20 min triple helix out scores a 2 hour sheet array

problem seems to be in fragment score, seems to be very difficult

to get the loops on the ends of the sheets to score.

bkoep Staff Lv 1

Thanks for the feedback retiredmichael! We've been wondering if the Fragment Filter has been problematic for different types of structures.

This puzzle has been reposted without the fragment filter here:
http://fold.it/portal/node/997791