Placeholder image of a protein
Icon representing a puzzle

903: Brain Cancer-Related Phosphorylated Id2

Closed since almost 12 years ago

Intermediate Overall Prediction Symmetry

Summary

Created
May 28, 2014
Expires
Max points
100
Description

Researchers at Dartmouth College are trying to determine the structure of the Id2 protein, and have asked for Foldit's help! Id2 is a regulatory protein that has been implicated in some brain cancers. The N- and C-terminal tails of Id2 are very important for the protein's function, but the structure of these regions is unknown. Help determine the structure of this Id2's tail regions in its symmetric dimer form! The central helices of this protein are held in place by constraints, although some slight movement is allowed. Also, note that the serine at position 14 has a negatively charged phosphate group attached. Read the blogpost for more info!

Top groups

  1. Avatar for FoldIt@Netherlands 11. FoldIt@Netherlands 10 pts. 11,348
  2. Avatar for Italiani Al Lavoro 12. Italiani Al Lavoro 8 pts. 11,155
  3. Avatar for Deleted group 13. Deleted group pts. 10,863
  4. Avatar for Richard Dawkins Foundation 14. Richard Dawkins Foundation 4 pts. 10,818
  5. Avatar for Natural Abilities 15. Natural Abilities 3 pts. 10,776
  6. Avatar for Repro-men 16. Repro-men 2 pts. 10,460
  7. Avatar for SETI.Germany 17. SETI.Germany 2 pts. 8,829
  8. Avatar for Piratenpartei Deutschland 18. Piratenpartei Deutschland 1 pt. 7,941
  9. Avatar for Team Schleswig-Holstein 19. Team Schleswig-Holstein 1 pt. 6,854
  10. Avatar for Mojo Risin' 20. Mojo Risin' 1 pt. 5,598
  1. Avatar for frood66 81. frood66 Lv 1 16 pts. 10,399
  2. Avatar for gcm24 82. gcm24 Lv 1 16 pts. 10,364
  3. Avatar for ManVsYard 83. ManVsYard Lv 1 15 pts. 10,341
  4. Avatar for mberna00 84. mberna00 Lv 1 15 pts. 10,328
  5. Avatar for SKSbell 85. SKSbell Lv 1 15 pts. 10,310
  6. Avatar for wisky 86. wisky Lv 1 14 pts. 10,218
  7. Avatar for Arthur Dent 87. Arthur Dent Lv 1 14 pts. 10,209
  8. Avatar for utaca 88. utaca Lv 1 13 pts. 10,191
  9. Avatar for ncm25_OLD 89. ncm25_OLD Lv 1 13 pts. 10,191
  10. Avatar for pgiles 90. pgiles Lv 1 13 pts. 10,188

Comments

wisky Lv 1

CASP is upon us, and we get a large symmetry puzzle!

Perhaps a a few more days are warranted for this puzzle? :)

wisky Lv 1

Not really from what I've seen. I've tried jpred and phyre and it's coming up with 60+ residues of loops

beta_helix Staff Lv 1

Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.