wisky Lv 1
CASP is upon us, and we get a large symmetry puzzle!
Perhaps a a few more days are warranted for this puzzle? :)
903: Brain Cancer-Related Phosphorylated Id2
Closed since almost 12 years ago
Intermediate Intermediate Overall Overall Prediction Prediction Symmetry SymmetrySummary
- Created
- May 28, 2014
- Expires
- Max points
- 100
Researchers at Dartmouth College are trying to determine the structure of the Id2 protein, and have asked for Foldit's help! Id2 is a regulatory protein that has been implicated in some brain cancers. The N- and C-terminal tails of Id2 are very important for the protein's function, but the structure of these regions is unknown. Help determine the structure of this Id2's tail regions in its symmetric dimer form! The central helices of this protein are held in place by constraints, although some slight movement is allowed. Also, note that the serine at position 14 has a negatively charged phosphate group attached. Read the blogpost for more info!
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Comments
spvincent Lv 1
Are there going to be any Secondary Structure predictions for this puzzle?
wisky Lv 1
Not really from what I've seen. I've tried jpred and phyre and it's coming up with 60+ residues of loops
beta_helix Staff Lv 1
Perhaps after the Scientist Chat we can decide if we want to add more days to this puzzle, or post a different round of it.
I'm running the SAM predictions right now, feel free to check them out while they are running:
http://compbio.soe.ucsc.edu/SAM_T08/results/target08-query-1401418399-9829/summary.html
This is the PDB page of ID2 (with the tails missing):
www.rcsb.org/pdb/explore/explore.do?structureId=4AYA
beta_helix Staff Lv 1
Here is the sequence logo predicted by the SAM server:
H = helix
E = sheet
C = loop (or coil)
The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.
retiredmichael Lv 1
we don't need extra days, lets quit while I am ahead
Timo van der Laan Lv 1
More days were not needed to catch you. ;-)