Placeholder image of a protein
Icon representing a puzzle

903: Brain Cancer-Related Phosphorylated Id2

Closed since almost 12 years ago

Intermediate Overall Prediction Symmetry

Summary

Created
May 28, 2014
Expires
Max points
100
Description

Researchers at Dartmouth College are trying to determine the structure of the Id2 protein, and have asked for Foldit's help! Id2 is a regulatory protein that has been implicated in some brain cancers. The N- and C-terminal tails of Id2 are very important for the protein's function, but the structure of these regions is unknown. Help determine the structure of this Id2's tail regions in its symmetric dimer form! The central helices of this protein are held in place by constraints, although some slight movement is allowed. Also, note that the serine at position 14 has a negatively charged phosphate group attached. Read the blogpost for more info!

Top groups

  1. Avatar for Void Crushers
    1. Void Crushers
    100 pts. 12,732
  2. Avatar for Beta Folders 2. Beta Folders 83 pts. 12,690
  3. Avatar for Go Science 3. Go Science 69 pts. 12,429
  4. Avatar for Anthropic Dreams 4. Anthropic Dreams 56 pts. 12,209
  5. Avatar for L'Alliance Francophone 5. L'Alliance Francophone 45 pts. 11,943
  6. Avatar for HMT heritage 6. HMT heritage 36 pts. 11,812
  7. Avatar for Contenders 7. Contenders 29 pts. 11,803
  8. Avatar for Deleted group 8. Deleted group pts. 11,715
  9. Avatar for Russian team 9. Russian team 18 pts. 11,666
  10. Avatar for Gargleblasters 10. Gargleblasters 14 pts. 11,511
  1. Avatar for spmm 11. spmm Lv 1 83 pts. 12,146
  2. Avatar for Reductone 12. Reductone Lv 1 81 pts. 12,101
  3. Avatar for cobaltteal 13. cobaltteal Lv 1 79 pts. 12,037
  4. Avatar for grogar7 14. grogar7 Lv 1 78 pts. 12,027
  5. Avatar for Madde 15. Madde Lv 1 76 pts. 11,985
  6. Avatar for pvc78 16. pvc78 Lv 1 75 pts. 11,964
  7. Avatar for yoyo washington 17. yoyo washington Lv 1 73 pts. 11,943
  8. Avatar for Galaxie 18. Galaxie Lv 1 72 pts. 11,915
  9. Avatar for christioanchauvin 19. christioanchauvin Lv 1 70 pts. 11,839
  10. Avatar for O Seki To 20. O Seki To Lv 1 69 pts. 11,812

Comments

wisky Lv 1

CASP is upon us, and we get a large symmetry puzzle!

Perhaps a a few more days are warranted for this puzzle? :)

wisky Lv 1

Not really from what I've seen. I've tried jpred and phyre and it's coming up with 60+ residues of loops

beta_helix Staff Lv 1

Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.