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909: Bonus CASP11 T0787 HIV-1 Env Symmetry Puzzle

Closed since almost 12 years ago

Advanced Overall Prediction Symmetry CASP11

Summary

Created
June 05, 2014
Expires
Max points
100
Description

The CASP organizers have told us that this HIV-1 Env protein is a trimer, so we are posting a Bonus Round for T0787 as a symmetric trimer! We've provided you with a RosettaServer model to start with. More info in the puzzle comments about different possible folds.

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  1. Avatar for JasperD 111. JasperD Lv 1 2 pts. 14,397
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  7. Avatar for GRandall64 117. GRandall64 Lv 1 1 pt. 14,372
  8. Avatar for persephone977 118. persephone977 Lv 1 1 pt. 14,372
  9. Avatar for Tac1 119. Tac1 Lv 1 1 pt. 14,370
  10. Avatar for vakobo 120. vakobo Lv 1 1 pt. 14,369

Comments

beta_helix Staff Lv 1

We provided you with Model 1 predicted by Robetta, but you can see that Robetta Models 3-5 also formed a trimer, but they are arranged differently:

http://rosettaserver.bakerlab.org/results.jsp?id=48566

Feel free to use those packing arrangements as inspirations for your own!

NOTE the short deadline on this Bonus CASP11 Puzzle, due to Target T0787 being due early on June 11th.
______________

More information about this CASP Target:
"CASP targets T0787 (gp41) and T0788 (gp120) are two parts of the HIV-1 Env complex, comprising three gp120 subunits and three gp41 subunits."
http://predictioncenter.org/casp11/target.cgi?id=36