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909: Bonus CASP11 T0787 HIV-1 Env Symmetry Puzzle

Closed since almost 12 years ago

Advanced Overall Prediction Symmetry CASP11

Summary

Created
June 05, 2014
Expires
Max points
100
Description

The CASP organizers have told us that this HIV-1 Env protein is a trimer, so we are posting a Bonus Round for T0787 as a symmetric trimer! We've provided you with a RosettaServer model to start with. More info in the puzzle comments about different possible folds.

Top groups

  1. Avatar for Russian team 11. Russian team 6 pts. 14,758
  2. Avatar for FoldIt@Netherlands 12. FoldIt@Netherlands 4 pts. 14,507
  3. Avatar for Repro-men 13. Repro-men 3 pts. 14,507
  4. Avatar for Team Schleswig-Holstein 14. Team Schleswig-Holstein 2 pts. 14,463
  5. Avatar for Richard Dawkins Foundation 15. Richard Dawkins Foundation 1 pt. 14,460
  6. Avatar for Natural Abilities 16. Natural Abilities 1 pt. 14,393
  7. Avatar for Geekdo 17. Geekdo 1 pt. 14,341
  8. Avatar for SETI.Germany 18. SETI.Germany 1 pt. 14,328
  9. Avatar for Eὕρηκα! Heureka! 19. Eὕρηκα! Heureka! 1 pt. 14,292
  10. Avatar for Italiani Al Lavoro 20. Italiani Al Lavoro 1 pt. 14,276
  1. Avatar for frank_6363 131. frank_6363 Lv 1 1 pt. 14,340
  2. Avatar for spvincent 132. spvincent Lv 1 1 pt. 14,340
  3. Avatar for Pibeagles 133. Pibeagles Lv 1 1 pt. 14,339
  4. Avatar for levl 134. levl Lv 1 1 pt. 14,336
  5. Avatar for lange 135. lange Lv 1 1 pt. 14,336
  6. Avatar for Altercomp 136. Altercomp Lv 1 1 pt. 14,333
  7. Avatar for Mlevanic 137. Mlevanic Lv 1 1 pt. 14,332
  8. Avatar for frostschutz 138. frostschutz Lv 1 1 pt. 14,328
  9. Avatar for matosfran 139. matosfran Lv 1 1 pt. 14,321
  10. Avatar for Lucas Roque 140. Lucas Roque Lv 1 1 pt. 14,317

Comments

beta_helix Staff Lv 1

We provided you with Model 1 predicted by Robetta, but you can see that Robetta Models 3-5 also formed a trimer, but they are arranged differently:

http://rosettaserver.bakerlab.org/results.jsp?id=48566

Feel free to use those packing arrangements as inspirations for your own!

NOTE the short deadline on this Bonus CASP11 Puzzle, due to Target T0787 being due early on June 11th.
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More information about this CASP Target:
"CASP targets T0787 (gp41) and T0788 (gp120) are two parts of the HIV-1 Env complex, comprising three gp120 subunits and three gp41 subunits."
http://predictioncenter.org/casp11/target.cgi?id=36