Placeholder image of a protein
Icon representing a puzzle

909: Bonus CASP11 T0787 HIV-1 Env Symmetry Puzzle

Closed since almost 12 years ago

Advanced Advanced Overall Overall Prediction Prediction Symmetry Symmetry CASP11 CASP11

Summary

Created
June 05, 2014
Expires
Max points
100
Description

The CASP organizers have told us that this HIV-1 Env protein is a trimer, so we are posting a Bonus Round for T0787 as a symmetric trimer! We've provided you with a RosettaServer model to start with. More info in the puzzle comments about different possible folds.

Top groups

  1. Avatar for Russian team 11. Russian team 6 pts. 14,758
  2. Avatar for FoldIt@Netherlands 12. FoldIt@Netherlands 4 pts. 14,507
  3. Avatar for Repro-men 13. Repro-men 3 pts. 14,507
  4. Avatar for Team Schleswig-Holstein 14. Team Schleswig-Holstein 2 pts. 14,463
  5. Avatar for Richard Dawkins Foundation 15. Richard Dawkins Foundation 1 pt. 14,460
  6. Avatar for Natural Abilities 16. Natural Abilities 1 pt. 14,393
  7. Avatar for Geekdo 17. Geekdo 1 pt. 14,341
  8. Avatar for SETI.Germany 18. SETI.Germany 1 pt. 14,328
  9. Avatar for Eὕρηκα! Heureka! 19. Eὕρηκα! Heureka! 1 pt. 14,292
  10. Avatar for Italiani Al Lavoro 20. Italiani Al Lavoro 1 pt. 14,276
  1. Avatar for brgreening 81. brgreening Lv 1 7 pts. 14,586
  2. Avatar for mimi 82. mimi Lv 1 6 pts. 14,586
  3. Avatar for flyflipper102 83. flyflipper102 Lv 1 6 pts. 14,579
  4. Avatar for spdenne 84. spdenne Lv 1 6 pts. 14,575
  5. Avatar for rinze 85. rinze Lv 1 6 pts. 14,571
  6. Avatar for dbuske 86. dbuske Lv 1 5 pts. 14,565
  7. Avatar for puxatudo 87. puxatudo Lv 1 5 pts. 14,563
  8. Avatar for cobaltteal 88. cobaltteal Lv 1 5 pts. 14,561
  9. Avatar for ralan-nsk 89. ralan-nsk Lv 1 5 pts. 14,548
  10. Avatar for joremen 90. joremen Lv 1 5 pts. 14,543

Comments

beta_helix Staff Lv 1

We provided you with Model 1 predicted by Robetta, but you can see that Robetta Models 3-5 also formed a trimer, but they are arranged differently:

http://rosettaserver.bakerlab.org/results.jsp?id=48566

Feel free to use those packing arrangements as inspirations for your own!

NOTE the short deadline on this Bonus CASP11 Puzzle, due to Target T0787 being due early on June 11th.
______________

More information about this CASP Target:
"CASP targets T0787 (gp41) and T0788 (gp120) are two parts of the HIV-1 Env complex, comprising three gp120 subunits and three gp41 subunits."
http://predictioncenter.org/casp11/target.cgi?id=36