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909: Bonus CASP11 T0787 HIV-1 Env Symmetry Puzzle

Closed since almost 12 years ago

Advanced Overall Prediction Symmetry CASP11

Summary

Created
June 05, 2014
Expires
Max points
100
Description

The CASP organizers have told us that this HIV-1 Env protein is a trimer, so we are posting a Bonus Round for T0787 as a symmetric trimer! We've provided you with a RosettaServer model to start with. More info in the puzzle comments about different possible folds.

Top groups

  1. Avatar for DSN @ Home 21. DSN @ Home 1 pt. 14,266
  2. Avatar for Deleted group 22. Deleted group pts. 13,928
  3. Avatar for Mojo Risin' 23. Mojo Risin' 1 pt. 13,602
  4. Avatar for test_group1 24. test_group1 1 pt. 10,923
  1. Avatar for MurloW 41. MurloW Lv 1 31 pts. 14,894
  2. Avatar for egran48 42. egran48 Lv 1 30 pts. 14,876
  3. Avatar for Mike Cassidy 43. Mike Cassidy Lv 1 29 pts. 14,872
  4. Avatar for alcor29 44. alcor29 Lv 1 28 pts. 14,872
  5. Avatar for fishercat 45. fishercat Lv 1 27 pts. 14,872
  6. Avatar for Ch Garnier 46. Ch Garnier Lv 1 26 pts. 14,859
  7. Avatar for Antibrad 47. Antibrad Lv 1 25 pts. 14,858
  8. Avatar for SKSbell 48. SKSbell Lv 1 24 pts. 14,846
  9. Avatar for g_b 49. g_b Lv 1 23 pts. 14,841
  10. Avatar for smholst 50. smholst Lv 1 23 pts. 14,823

Comments

beta_helix Staff Lv 1

We provided you with Model 1 predicted by Robetta, but you can see that Robetta Models 3-5 also formed a trimer, but they are arranged differently:

http://rosettaserver.bakerlab.org/results.jsp?id=48566

Feel free to use those packing arrangements as inspirations for your own!

NOTE the short deadline on this Bonus CASP11 Puzzle, due to Target T0787 being due early on June 11th.
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More information about this CASP Target:
"CASP targets T0787 (gp41) and T0788 (gp120) are two parts of the HIV-1 Env complex, comprising three gp120 subunits and three gp41 subunits."
http://predictioncenter.org/casp11/target.cgi?id=36