Placeholder image of a protein
Icon representing a puzzle

913: CASP11 T0797: WeFold Docking

Closed since almost 12 years ago

Intermediate Overall Prediction CASP11

Summary

Created
June 10, 2014
Expires
Max points
100
Description

This 44 residue CASP11 Target is a little different, because T0797 and T0798 are two parts of the same complex. In this puzzle, we are giving you Robetta's T0797 prediction to model against a frozen server prediction for T0798, which was selected by our WeFold collaborators. The backbone of the larger T0798 region is completely frozen for this puzzle, so your job is to dock the short T0797 model against T0798 as best you can! More details in the puzzle comments.

Top groups

  1. Avatar for Repro-men 11. Repro-men 4 pts. 7,739
  2. Avatar for Deleted group 12. Deleted group pts. 7,731
  3. Avatar for Geekdo 13. Geekdo 2 pts. 7,631
  4. Avatar for FoldIt@Netherlands 14. FoldIt@Netherlands 1 pt. 7,614
  5. Avatar for SETI.Germany 15. SETI.Germany 1 pt. 7,600
  6. Avatar for Team Schleswig-Holstein 16. Team Schleswig-Holstein 1 pt. 7,563
  7. Avatar for Natural Abilities 17. Natural Abilities 1 pt. 7,560
  8. Avatar for Richard Dawkins Foundation 18. Richard Dawkins Foundation 1 pt. 7,550
  9. Avatar for Italiani Al Lavoro 19. Italiani Al Lavoro 1 pt. 7,484
  10. Avatar for DSN @ Home 20. DSN @ Home 1 pt. 6,707
  1. Avatar for nicobul 51. nicobul Lv 1 22 pts. 7,715
  2. Avatar for hpaege 52. hpaege Lv 1 21 pts. 7,713
  3. Avatar for mimi 53. mimi Lv 1 21 pts. 7,712
  4. Avatar for pvc78 54. pvc78 Lv 1 20 pts. 7,709
  5. Avatar for SKSbell 55. SKSbell Lv 1 19 pts. 7,707
  6. Avatar for drjr 56. drjr Lv 1 19 pts. 7,703
  7. Avatar for Paulo Roque 57. Paulo Roque Lv 1 18 pts. 7,700
  8. Avatar for auntdeen 58. auntdeen Lv 1 17 pts. 7,697
  9. Avatar for cobaltteal 59. cobaltteal Lv 1 17 pts. 7,690
  10. Avatar for agua carbonatada 60. agua carbonatada Lv 1 16 pts. 7,689

Comments

beta_helix Staff Lv 1

This is what the CASP organizers have told us about this protein:

CASP targets T0797 and T0798 are two parts of the PKGII leucine zipper /Rab11b complex comprising two zipper subunits and two Rab11b subunits…
The main modeling task here is to get structure of the leucine zipper in correct conformation with the Rab11b GTPase that remodels upon binding.

http://predictioncenter.org/casp11/target.cgi?id=51

Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

Susume Lv 1

I think you are saying the native contains two helices (which make a leucine zipper) and two blobs, and we have been given one helix and one blob to stick together. The leucines on our helix are supposed to stick to the leucines on the other helix, so they should not be hidden by the blob.