Beginner Puzzle (<150): Docking Design

Closed since over 11 years ago

Summary

• Created: January 27, 2014
• Expires: August 14, 2014 at 23:00 UTC
• Max points: 100

Description

We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.



START HERE:

If you are new to Foldit, here are detailed instructions to get you started:

http://fold.it/portal/node/988864

_____________________________

If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :

- try all puzzles not only "Beginners" ones,

- fold first the ones you like the most,

- try it by yourself to understand what works and what doesn't,

- ask for tips in global chat when you think you don't understand something.

Make sure you have followed these tutorials:

- Lonely Sheets,

- Lock and Lower,

- Rebuild,

- Structure and Rebuild,

- Movin' Along,

- Control over Clashing,

- Intro to Design,

- Swappin' Sidechains,

- Mass Mutate,

- Insertion and Deletion

before starting this puzzle.

Top groups

• 1. Italiani Al Lavoro 100 pts. 9,258
• 2. L'Alliance Francophone 81 pts. 9,251
• 3. Gargleblasters 64 pts. 9,239
• 4. 7Monkeys 50 pts. 9,234
• 5. Deleted group pts. 9,219
• 6. SETI.Germany 30 pts. 9,216
• 7. Minions of TWIS 23 pts. 9,145
• 8. Team China 17 pts. 9,136
• 9. xkcd 12 pts. 9,134
• 10. HMT heritage 9 pts. 9,117

Top soloists

• 41. mirjamvandelft 77 pts. 9,200
• 42. roundrightfarm 76 pts. 9,199
• 43. Qez 76 pts. 9,197
• 44. willy50 75 pts. 9,197
• 45. Erik Rust 75 pts. 9,197
• 46. Tahj 74 pts. 9,197
• 47. PhilipReichel 74 pts. 9,196
• 48. kodi4444 73 pts. 9,196
• 49. venij 73 pts. 9,193
• 50. MadnessX 72 pts. 9,192