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Beginner Puzzle (<150): Docking Design

Closed since over 11 years ago

Beginner Beginner

Summary

Created
January 27, 2014
Expires
Max points
100
Description

We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.



START HERE:

If you are new to Foldit, here are detailed instructions to get you started:

http://fold.it/portal/node/988864

_____________________________


If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :

- try all puzzles not only "Beginners" ones,

- fold first the ones you like the most,

- try it by yourself to understand what works and what doesn't,

- ask for tips in global chat when you think you don't understand something.


Make sure you have followed these tutorials:

- Lonely Sheets,

- Lock and Lower,

- Rebuild,

- Structure and Rebuild,

- Movin' Along,

- Control over Clashing,

- Intro to Design,

- Swappin' Sidechains,

- Mass Mutate,

- Insertion and Deletion


before starting this puzzle.

Top groups

  1. Avatar for FoldingCondors 31. FoldingCondors 1 pt. 8,424
  2. Avatar for Window Group 32. Window Group 1 pt. 8,239
  3. Avatar for Deleted group 33. Deleted group pts. 7,985
  4. Avatar for CHEN 4801 34. CHEN 4801 1 pt. 7,530
  5. Avatar for SETIKAH@KOREA 35. SETIKAH@KOREA 1 pt. 7,530
  1. Avatar for hewertson 761. hewertson Lv 1 1 pt. 8,797
  2. Avatar for santzi 762. santzi Lv 1 1 pt. 8,797
  3. Avatar for Delaram93 763. Delaram93 Lv 1 1 pt. 8,797
  4. Avatar for MuggleDave 764. MuggleDave Lv 1 1 pt. 8,796
  5. Avatar for monolith1729 765. monolith1729 Lv 1 1 pt. 8,793
  6. Avatar for jdeast 766. jdeast Lv 1 1 pt. 8,792
  7. Avatar for perling 767. perling Lv 1 1 pt. 8,792
  8. Avatar for tguerrero90 768. tguerrero90 Lv 1 1 pt. 8,792
  9. Avatar for Big G 769. Big G Lv 1 1 pt. 8,789
  10. Avatar for riber79 770. riber79 Lv 1 1 pt. 8,788

Comments

rjsthethird Lv 1

Is it just me or did the scoring on this change when the program was last updated? I had a score of 9148 saved, but when I opened it the score came in at 8818.

upquark1 Lv 1

Same here. My score was 9,196 a couple days ago. Now I can't get back for the life of me. My best is now 8,928.7

jstoddard Lv 1

Does the fragment have to be a helix? The instructions suggested that any amino acid could be mutated on the helix. I didn't think to try explore alternate loops until a couple days ago.