Beginner Puzzle (<150): Docking Design

Closed since over 11 years ago

Summary

• Created: January 27, 2014
• Expires: November 06, 2014 at 23:00 UTC
• Max points: 100

Description

We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.



START HERE:

If you are new to Foldit, here are detailed instructions to get you started:

http://fold.it/portal/node/988864

_____________________________

If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :

- try all puzzles not only "Beginners" ones,

- fold first the ones you like the most,

- try it by yourself to understand what works and what doesn't,

- ask for tips in global chat when you think you don't understand something.

Make sure you have followed these tutorials:

- Lonely Sheets,

- Lock and Lower,

- Rebuild,

- Structure and Rebuild,

- Movin' Along,

- Control over Clashing,

- Intro to Design,

- Swappin' Sidechains,

- Mass Mutate,

- Insertion and Deletion

before starting this puzzle.

Top groups

• 1. Penn State Biomolecular Engineers 100 pts. 9,286
• 2. Rice Biochemistry 87 pts. 9,231
• 3. Protein Pirates 74 pts. 9,201
• 4. xkcd 64 pts. 9,188
• 5. Anthropic Dreams 54 pts. 9,187
• 6. Crunching Family 46 pts. 9,178
• 7. Minions of TWIS 38 pts. 9,170
• 8. Go Science 32 pts. 9,167
• 9. Deleted group pts. 9,163
• 10. Italiani Al Lavoro 22 pts. 9,143

Top evolvers

No scores of this type to display!

Comments

[rjsthethird]

Is it just me or did the scoring on this change when the program was last updated? I had a score of 9148 saved, but when I opened it the score came in at 8818.

[upquark1]

Same here. My score was 9,196 a couple days ago. Now I can't get back for the life of me. My best is now 8,928.7

[jstoddard]

Does the fragment have to be a helix? The instructions suggested that any amino acid could be mutated on the helix. I didn't think to try explore alternate loops until a couple days ago.