Placeholder image of a protein
Icon representing a puzzle

Beginner Puzzle (<150): Docking Design

Closed since over 11 years ago

Beginner Beginner

Summary

Created
January 27, 2014
Expires
Max points
100
Description

We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.



START HERE:

If you are new to Foldit, here are detailed instructions to get you started:

http://fold.it/portal/node/988864

_____________________________


If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :

- try all puzzles not only "Beginners" ones,

- fold first the ones you like the most,

- try it by yourself to understand what works and what doesn't,

- ask for tips in global chat when you think you don't understand something.


Make sure you have followed these tutorials:

- Lonely Sheets,

- Lock and Lower,

- Rebuild,

- Structure and Rebuild,

- Movin' Along,

- Control over Clashing,

- Intro to Design,

- Swappin' Sidechains,

- Mass Mutate,

- Insertion and Deletion


before starting this puzzle.

Top groups

  1. Avatar for Penn State Biomolecular Engineers
    1. Penn State Biomolecular Engineers
    100 pts. 9,286
  2. Avatar for Rice Biochemistry 2. Rice Biochemistry 87 pts. 9,231
  3. Avatar for Protein Pirates 3. Protein Pirates 74 pts. 9,201
  4. Avatar for xkcd 4. xkcd 64 pts. 9,188
  5. Avatar for Anthropic Dreams 5. Anthropic Dreams 54 pts. 9,187
  6. Avatar for Crunching Family 6. Crunching Family 46 pts. 9,178
  7. Avatar for Minions of TWIS 7. Minions of TWIS 38 pts. 9,170
  8. Avatar for Go Science 8. Go Science 32 pts. 9,167
  9. Avatar for Deleted group 9. Deleted group pts. 9,163
  10. Avatar for Italiani Al Lavoro 10. Italiani Al Lavoro 22 pts. 9,143
  1. Avatar for jcbyrne 1101. jcbyrne Lv 1 1 pt. 7,530
  2. Avatar for HijazFadi22014 1102. HijazFadi22014 Lv 1 1 pt. 7,530
  3. Avatar for miro1157 1103. miro1157 Lv 1 1 pt. 7,530
  4. Avatar for hyproh 1104. hyproh Lv 1 1 pt. 7,530
  5. Avatar for asantos 1105. asantos Lv 1 1 pt. 7,530
  6. Avatar for geb13 1106. geb13 Lv 1 1 pt. 7,530
  7. Avatar for sumontro 1107. sumontro Lv 1 1 pt. 7,530
  8. Avatar for crystalsutton 1108. crystalsutton Lv 1 1 pt. 7,530
  9. Avatar for ilovebagugu 1109. ilovebagugu Lv 1 1 pt. 7,530
  10. Avatar for ClarkCody22014 1110. ClarkCody22014 Lv 1 1 pt. 7,530

Comments

rjsthethird Lv 1

Is it just me or did the scoring on this change when the program was last updated? I had a score of 9148 saved, but when I opened it the score came in at 8818.

upquark1 Lv 1

Same here. My score was 9,196 a couple days ago. Now I can't get back for the life of me. My best is now 8,928.7

jstoddard Lv 1

Does the fragment have to be a helix? The instructions suggested that any amino acid could be mutated on the helix. I didn't think to try explore alternate loops until a couple days ago.