The protein is more stable, doesn't seem as prone to completely disappearing. But the responsiveness without the "filters off" toggle function impedes fine control of what you're doing to the protein (seems you see every fifth frame when you try to move, is jerky). Combined with the above two comments, I think this release still has a long way to go to beat the 32bit version. Definitely not a fan of the no timer on the action "clock", (which came back when I went in and restored my advanced GUI in the View, by the way, so I will start another with advanced GUI view (which should have loaded with my options.txt file but did not, apparently)) the removal of the ability to toggle filters , and no way to see how your moves are affecting the overall score as you work (possibly due to the basic GUI use early on.).
Also, 64bit client doesn't appear to want to minimize. Don't know if this is by design but typically I can minimize a client that's running a script and this isn't letting me.
Hi all,
Thanks for the detailed report. Wanted to give an update on the dev end of this:
We are able to reproduce the bug and are investigating. Thank you as always for your patience.
New Odd behavior for the latest Devprev 64 bit Mac version.
At CI 1.0 all seems well. However, if you wiggle the segment at anything less than CI 1.0, the protein "decomposes"… the backbone disintegrates into a mass of backbone issue bubbles and the protein falls apart.
I brought in the Aflatoxin puzzle to see how it acted and it completely fell apart with the locked segments floating out into space and the aflatoxin losing its moorings and also flying off. It stays within the puzzle space but doesn't eventually resolve.

It doesn't display this behavior with the current sketchbook puzzle but it does still move (zoom) the protein in space and off screen. Q doesn't recover it… which is what I think was causing the Aflatoxin to fly apart.
Is the Mac version rolled back to the old one that made proteins effectively disappear?
So, on the sketchbook puzzle with one band "tether" here's what happened when it was wiggled at .08 CI… instead of compressing as one might expect, the protein starts to pull apart… moving around on the screen and pulling against the band.
I shared both examples with scientists. Good luck finding the invisible one!
Just downloaded today's 64-bit release, and tried it on Puzzle 1558, starting from scratch. Did a shake, select all, "5", shake, wiggle. Protein hops around, but q key brings it back. Then added a single band, reduced strength to 0.25, and wiggled, and the protein disappeared, never to come back. Running a script on it (QuakeR, by Gary Forbis) crashed the client. Will try adding a band to space to the protein, see if that helps.
Adding the band did help, sort of. I reset the puzzle, shake, select all, "5" to create helices, shake, add band to one end, wiggle. Bounces all over (even the end of the band in space), and deforms the helices, but I could still see it. Froze the helices, wiggled, it bounced around but not so much. Banded to pull them parallel, again bouncing, but stayed visible.
Completely fresh install, btw.