Some texts remain in english
Tutorials
When you think SHAKE has done a good enough job, you can press it again to Stop.
"Just like SHAKE tries to take care of sidechains, WIGGLE tries to let Foldit improve the backbone. WIGGLE gets stuck if it cannot increase the score. Click this button again to stop the tool
"When you're close, you can remove the bands and Wiggle again." (??)
Sheets like to be alongside each other. Remember, hydrogen bonds are great for your score
"You might have guessed by now, but color is used to show how well part of the protein is folded. Green is good, red is not so good."
"oops the protein is falling apart. \n Want to reset?
"Orange pointing in, blue pointing out."
"Changing the structure of the protein can help you see a solution better, and also affects Rebuild and Tweak."
"To enter Structure mode, click the Modes tab and choose Structure, or press 2."
"Once you've done that, try using tweak to flip the sheet down"
"In this puzzle, the natural folded state of the protein, called a NATIVE, is known. Use the tools available to match the protein with the guide."
Use the tools available to match the protein with the guide.
If you haven't discovered it yet, you can attach a rubber band from the protein to a point in empty space.
Rubber bands also affect the pull tool, not just wiggle
"In an Electron Density puzzle, we only have data on the rough shape of the protein."
Adjust the THRESHOLD to change the thickness of the density region
Use Shake, Wiggle, and careful moving to fold the protein into the best possible shape that fits inside the predicted region
In exploration puzzles like this one, your goal is to find a solution that is different from the starting structure."
"The red areas are contacts present in the starting structure. White areas are new contacts, which increase your score multiplier."
"To avoid this, lower the CLASHING IMPORTANCE. This lets Wiggle keep making small adjustments even if the protein is packed too tight."
"A lower Clashing Importance also lets you make moves that add clashes without unravelling the protein, like pulling on a tangled strand."
"These levels will introduce the powerful ALIGNMENT tool! It will let you use the structures of real proteins, called TEMPLATES, by THREADING."
"When you THREAD, your protein will try to fit onto the 3D TEMPLATE where the cylinders are."
"Now that you've threaded it, try a shake and wiggle!"
"You can reset, undo, or redo with these buttons."
"Try to line up the colors. It's okay if there are spaces, but fewer spaces is better. Click here to thread when they match well!"
"If shake and wiggle doesn't work, try a different alignment!"
"To enter Design Mode, click the Modes tab and choose Design, or press 4."
"Now some sidechains are too small, causing voids!"
"You've earned a new tool! Mutate Sidechains is like Shake, but may mutate designable sidechains."
This red line is a CONSTRAINT, indicating that the segments it connects should be closer together
"Left click on the ligand to bring up MOVE tool. RIGHT-button-drag to move left, right, up, and down, LEFT-button-drag to rotate and SHIFT-LEFT(or MIDDLE)-button-drag to move ligand Into/Out of screen
"When the ligand is in a good place, try a wiggle!
After moving the ligand closer, use WIGGLE SIDECHAINS to wiggle the sidechains and the ligand at the same time. Try and compare it to Shake Sidechains
Help on tweak
Flip and shift in this direction
Rotate in this direction
Electron density options
