We don't want you to forget - after all, the week will fly by before you know it.
The Date: 17 September 2015 (Thursday) Add your questions to this post! If you don't have a question yet? Bookmark that post and add them closer to the event. Science suggestions? Try the forum for feedback first on your idea from other players. Science related bug? Post it in the puzzle comments or repro steps in feedback!
The location: #veteran, IRC (Get help with chat here.)
The Time: 2000-2100 (or so, but the official chat ends after an hour) GMT (aka 1300-1400 PT)
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The Topics: Science (with a side of Development) chat!
Looking for inspiration? Follow-up on previous topics? Read our previous chats.
We can't wait to see you there.
The Social function with the Buddies has been broken for a while. Old buddies still can be viewed, but newer members of my group cannot be added. This negatively impacts the interaction between team members. Why can't this function be fixed?
Hi there!
Please file bugs in the feedback section, where it can be properly seen and addressed by developers.
Thanks!
Please clarify if this is a dev chat or a sci chat. Thanks.
I'm curious how the new Drug Design tools are progressing.
Could there be puzzles this fall?
http://fold.it/portal/node/2000972
"The Topics: Science (with a side of Development) chat!"
jeff101's drug design question below is a perfect example of a "side of development" type question that we can expect during this chat.
Arcsign asked a great question in chat recently: "when predicted contacts are generated initially, and they are generated for one subunit of an N-mer, how likely is it that 'odd' looking contacts belong to an interface between subunits, rather than an interface between different sections of the same subunit?"
Since the contact predictions you give us are based on co-evolution, it seems reasonable that interface contacts would get picked up by the prediction algorithm just as readily as intra-monomer contacts. Is there any way for us to tell them apart?
It is a hundred year chat…
Is it possible to add a "linearize" function that will take the tangled mess of any polypeptide loaded and make it one long, perfectly straight line, like we see for "de-novo" puzzles. Kinda like a "De-novo" button?
To linearize the protein so it looks like in a "de-novo" puzzle, do as listed below:
(1) Go to the Selection Interface.
(2) Shift-click both ends of the protein to select all residues of the protein.
If you are coloring as Rainbow, the entire protein becomes dark blue.
Also, in the upper left it should say how many residues are selected.
(3) Click on button J for sheet. Curly purple arrows should appear.
If you are viewing as Cartoon, you should see the secondary structure change to all sheets.
(4) Click on button 5 to idealize the secondary structure.
The protein should become all linear and the score will change.
(5) Click on the background to select no residues.
(6) Click on reset secondary structure to restore the given secondary structure.
If you are viewing as Cartoon, you should see the secondary structure change
from all sheets to a mix of helices (H), sheets (E), and loops (L).
