sarelf Lv 1
The results from the inhibitor design puzzle have come in and it appears that many of the players fully identified all of the hot-spot residues - those are the residues on the inhibitor that are crucial to inhibition in the natural inhibitor. This is very impressive because getting these hot-spot residues correctly requires a combination of tools that Rosetta provides, including sidechain redesign and minimization.
We will next provide several other puzzles similar to this one, where we know what the hot-spot residue identities are, but we shaved those off and you can try to recapitulate them. The first in this set of puzzles is the structure of human growth hormone bound to its receptor.
Following a few of these puzzles we would like to ask for your help in improving our designs for a variety of protein targets. I'm looking forward to your participation and am eager to see what design possibilities you could uncover that we miss.