v_mulligan Lv 1
A few players have pointed out a small problem in puzzle 1000 that can be exploited to get a few extra points: if the non-designable residues at the start and end of the peptide are deleted, and then reinserted, they become designable, meaning that you can now design five positions instead of the intended three. We don't think that this will invalidate the scientific results from this puzzle, so rather than re-post it, we are announcing the exploit so that no one has an unfair advantage. Feel free to design all five positions using this exploit.