Susume Lv 1
Here is a recent paper from the Baker Lab in which they inserted one small designed protein into another, thus creating a larger designed protein. This demonstrates a new method for creating larger designed proteins, and it may be a pathway by which some natural proteins evolved from smaller building blocks.
Precise assembly of complex beta sheet topologies from de novo designed building blocks
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737653/