Susume Lv 1
Personally, I don't understand what happens in this movie. Do anybody understand why the extremities move from small distance (blue) to high distance (red)? Distance of what ? (I don't see distance moving, only colour of the distance).
Videos of proteins in motion with Cryo EM
Started by Susume
Bruno Kestemont Lv 1
Personally, I don't understand what happens in this movie. Do anybody understand why the extremities move from small distance (blue) to high distance (red)? Distance of what ? (I don't see distance moving, only colour of the distance).
jeff101 Lv 1
https://youtu.be/H4j2-pgdelQ shows a video.
Comparing it with Fig.6 in the Results section
of https://www.nature.com/articles/s41467-020-18403-x
it looks like the image begins all blue, where blue
parts have moved 0 Angstroms from their starting
positions. The motions are small (up to 10 Angstroms),
so the color-coding helps to see them. As you watch
the video, parts that have moved the most turn red
while parts that have moved very little stay blue.
The paper's Supplementary Information at
https://www.nature.com/articles/s41467-020-18403-x#Sec27
contains 13 Supplementary Movies.jeff101 Lv 1
Personally, I don't understand what happens in this movie. Do anybody understand why the extremities move from small distance (blue) to high distance (red)? Distance of what ? (I don't see distance moving, only colour of the distance).
jeff101 Lv 1
The team of 2017 Nobel laureate Joachim Frank at Columbia, along with several collaborators, have found a way to extract still image data from cryo-EM images of proteins and combine it with machine learning and molecular dynamics modeling to produce videos of those proteins in motion, such as opening and closing:
https://www.cuimc.columbia.edu/news/new-technique-biologists-capture-molecules-motion