Hand Fold Proteins

[karstenw]

I was thinking that there really is no reason that we couldn't get the regular version of a protein at the same time that we get the hand fold only version. This could be nice because we can test our own hand fold immediately.

[bertro]

I have to disagree because the regular version will "influence" the hand-folded one TOO much in my opinion since the regular one will certainly give a better score each time.

[Timo van der Laan]

In my opinion (now being nr 1 at handfolding and still hating it) handfolding should be replaced by non sharing and no picture sharing but allowing all the scripts.

[MurloW]

I can totally see why they want us to handfold first, there's bound to be greater diversity and it's a greater challenge for us having to work out little kinks ourselves. They shouldn't give us both puzzles at the same time, imho, it would even further discourage playing the handfolds. What they should do is shorten the timespan on the handfold, atm we're forced to put serious mindnumbing rebuild and fuzing work into them if we want a respectful rank. If they were only, say 3 days long, we could just throw a bunch of configurations together, see what kinda scores and work on those with scripts later on. That's what I already do. I think that would also give less experienced players a chance to get a good rank, instead of only the folders with end-game knowledge.

Also, I don't think all scripts should be allowed, but some tiny things should.
Like setting all bands to their current length, it's a great pain to do manually when u have a lot of bands, and there's no easier way on handfolds. Or information gathering recipes, like jpred helper, or AA Copy Paste Compare.

[bertro]

Remember anyone can capture a screen or window on a computer and share it if they want.

So it NOT possible to stop picture sharing at all.

[brow42]

Yes, I would be interested in seeing LUA 2 scripts, with "do-er" functions wiggle, shake, and rebuild, idealize (and tweak if it exists) disabled.

[Timo van der Laan]

Second this. Said it before.

[AsDawnBreaks]

You have responded non this, but for those who don't know, I submitted a feedback to have change band length included: fold.it/portal/node/995038

[christioanchauvin]

In my opinion,hand folding is a complete loss of time.
The diversity argument is weak,because there are more messy solutions than promising ones.
Furthermore you can start the next client where scripts are authorized from scratch and
it may be safer to do so.
I never understood the argument saying "we are not able to select the best solutions
which give the best rmsd on CASP so we want to have more diversity in the solutions"
How on earth does this help you selecting the best solutions with rmsd criterium????
There is an analysis to do to check from where comes the discrepancy between the best
foldit solutions and the rmsd criterium breaking down the score components in a variance analysis.
.If i had to make an educated guess,i would look
in the sidechains configurations.many recipes use wiggle all command which leave lots of poins
that a wiggle sidechains would have found.Finally lot of work has been done on wiggle backbone
and little on wiggle sidechains.obviously I may be wrong,and my view is biased as i hate
hand folding and am not good at it.

[drumpeter18yrs9yrs]

As a fellow hand-folding lover, I have to disagree with this. It contradicts the purpose of hand-folding. I think hand-folding is fine just the way it is.