We all found that local wiggle sequence is not working anymore.
If we make totally "fresh" alignment form scratch mad pump it using bands, rebuilds etc it was common that any LWS script make from few to even few hundred points. Now series of them make only 1-2 points!
LWS endgame strategy always make cool score boost and last day/hour/minutes was always exciting because sometimes someone form #20 (or lower!) get in top 5 only by LWS.
We miss that days, please change it back to that state. Looks like changes in wiglle behavior are much deeper than we all thought.
At this point walking it total waste of time.
yes I agree rav - even in main, which is supposed to be unchanged, LWS is not working, which I suggest means that we are all working with much stiffer puzzles. Also the multiple alignment puzzles often had slightly stretched or compressed segments which shook out during LWS gaining points without stiffening, there seems to be no way to get those out now.
I am also seeing segments which are not glycine or proline bent in half with bad scores (not on hairpins)and they don't rebuild or wiggle out - isoleucine is one in particular, that may or may not be related .
Could this just be an issue with CASP ROLL puzzles?
We have reverted everything back to what Foldit was like before CASP ROLL started, so perhaps it is something about these CASP ROLL targets.
Since we haven't been able to post any other prediction puzzles, it could be something to do with the starting server models, although we are giving you models from 2 very different servers (Quark/Zhang & RosettaServer).
Is this also true with the design puzzles where you are able to design certain regions from scratch?
What about the Beginner Puzzles (since the current puzzle was posted a couple months ago)?
Same thing is in last QTTN puzzles. This is not CASP puzzles only.
I made denovo (not using threading etc.) to about 90% of my best score and tried to walk it - got 2 points…
I have noticed for quite a while that walking was not helping me any more but I assumed it was because the wiggles and shakes have squeezed more points out than previously and there is less left for walkers to take. In that case, we haven't really lost anything, just the rush of a final points gain.
I also feel that the competition (not the protein) has become a lot stiffer. I am lucky to make the top 100 folders in a puzzle now whereas a few months ago I was easily in the top 50 or less.
I agree that the competition has become more intense which is great - more good folders - but I don't understand why walking has changed - walking early often locked your protein into really nasty minima so rather like running with Wiggle Accuracy set high, you get early points but loose flexibility when you really need it.
Yes, only rebuild or relly stong banding was need to make it flexible again. Now it is looking like "pre-walked" every wiggle and nothing can make it flexible again. Maybe "something" is changed in CI http://fold.it/portal/node/990990 ? It really looks like CI is working in "narrow" range.
I also have found the flipping side chains is not giving up as many points as previously; I assumed it like walking had lost its effectiveness because of all the play with CI&shaking&wiggling using scripts. Now I wonder if something else has happened.
True. Acid Tweaker and clones not making much on good fuzed one.
Yes i have seen the lessening of the points from walkers at the end game, this may have something to do with the casp puzzles because they are generations of the same puzzles, worked on by many many people and every script which include walkers in each genneration of the casp contests?
Like shapening a pencil to a point, we are comming closer and closer to the refind solutions of casp?
My feeling are that the banders and rebuilders may have gotton much better at shaking out those last few points befor you need to walk at the end.
Also, more people may be using more walkers earlier in the game, when they evo from a red line. This distrubuted walking may help to settle the protein sooner and better, thereby reducing the amount of walking that is needed at the end?
