Wiggle Lock on puzzle 625

Started by Susume

Bletchley Park Lv 1

What happens to an evo that was saved earlier from the sticky state and is reloaded ?
Will that be sticky still or will that now improve as well ?
Do we need to completely restart the puzzle in a clean track and start all over or can we resume from a known solution with better wiggle ?

Darkknight900 Lv 1

There is an improvement i saw already, BUT you have to go backwards… if you are stuck then you are also stuck after the update!
Restart the puzzle and it will go easier…

What i saw is:
Improvement of same recipe before the update:
7874 -> 7880
and after the update:
7874 -> 7894 just doing the same things

A little improvement but not really much…

gitwut Lv 1

I read the comments for this puzzle and am a bit frustrated. I seriously doubt that much of anything useful will be obtained from the results.

1) Very few players are pursuing the main goal of trying to create bonds to the sugar molecule. They do at first, but find that they get much higher scores by ignoring the molecule altogether.

2) Due to the many bugs seemingly associated with only this puzzle, it is doubtful that any of the results (even if bonds were pursued) will be optimal.

I have a keen interest in wanting this puzzle to be successful. My wife went into septic shock a couple of times over a period of 3 years before finally succumbing to septicemia. I would really like to participate in helping to improve treatments for this condition.

I hope that Foldit will consider doing another sepsis puzzle once the bugs have been worked out. I would suggest too that there be a bonus score added for each bond created to the molecule–enough so that it is more rewarding to do so than not. If that's not feasible, perhaps a requirement for "x" molecule bonds to be present for a score to count.

BootsMcGraw Lv 1

It's not just you. I hand-worked this puzzle to a respectable score, then ran some mutating scripts on it. The end result was a 7900+ point solution with NO bonds to the sugar molecule.

I wrapped the protein well enough around the sugar that simple manual substitution of sidechains allowed me to make six or seven H-bonds to it. And the score dropped to under 7500. Shaking the sidechains at that point pushed all the bond-makers but one away from the sugar molecule. Wiggling the backbone broke most of the H-bonds, as well.

This makes no sense, unless there are errors in the scoring function. I did the right thing… and got penalized for it. Go figure.

Darkknight900 Lv 1

I also have to say that there is something wrong with the bonding scoring! I arranged some sheets around but they bond rarely just with hard bonds to just 2-3 Points per Bonding! And because of that the position of a sidechain is far more important to the game as the bonding, i think this will also explain the rare bonding to the molecule…

Seth Cooper Staff Lv 1

To help determine why the puzzle seems to not be moving much, can someone post:

  • name of a shared solution to start from
  • the set of steps tried to get the protein to move
  • what you would expect to happen, and what did happen