jeff101 Lv 1
In Foldit small molecule design puzzles, if we made a ligand with -SH groups on it (like in cysteine), could the ligand form disulfide bonds with nearby cysteine sidechains from the protein?
Can Foldit ligands form disulfide bonds with cysteines in the protein?
Started by jeff101
rmoretti Staff Lv 1
We don't annotate ligand -SH groups as "disulfide-able", so Foldit won't ever make the protein-ligand disulfide connection.
(That's not to say such a bond couldn't happen with an actual drug - it's just that we don't really consider covalent connections between ligands and proteins currently within Foldit.)