Placeholder image of a protein
Icon representing a puzzle

1002: 22 Residue Peptide Design

Closed since over 11 years ago

Intermediate Overall Design

Summary

Created
October 20, 2014
Expires
Max points
100
Description

This puzzle is aimed at designing short peptides that fold into stable structures. We encourage the use of multiple disulfide bonds, but discourage GLY residues, which will score especially poorly here. See the puzzle comments for more information about filters. The Baker lab will run folding predictions on your best designs, and the the ones that perform well will be synthesized and further validated for structural stability. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Natural Abilities 21. Natural Abilities 1 pt. 8,326
  2. Avatar for freefolder 22. freefolder 1 pt. 8,264
  3. Avatar for Eὕρηκα! Heureka! 23. Eὕρηκα! Heureka! 1 pt. 8,256
  4. Avatar for xkcd 24. xkcd 1 pt. 8,221
  5. Avatar for Czech National Team 25. Czech National Team 1 pt. 8,158
  6. Avatar for Cell Biology Fall 2014 with Smith 26. Cell Biology Fall 2014 with Smith 1 pt. 8,133
  7. Avatar for Mr. Baxley's Students 27. Mr. Baxley's Students 1 pt. 8,130
  8. Avatar for Deleted group 28. Deleted group pts. 7,857
  9. Avatar for DSN @ Home 29. DSN @ Home 1 pt. 7,784
  10. Avatar for DCC Folders 30. DCC Folders 1 pt. 7,781
  1. Avatar for Grom 121. Grom Lv 1 3 pts. 8,385
  2. Avatar for frostschutz 122. frostschutz Lv 1 3 pts. 8,381
  3. Avatar for SouperGenious 123. SouperGenious Lv 1 3 pts. 8,375
  4. Avatar for Waverka.10 124. Waverka.10 Lv 1 3 pts. 8,372
  5. Avatar for darioarena 125. darioarena Lv 1 3 pts. 8,370
  6. Avatar for Psych0Active 126. Psych0Active Lv 1 3 pts. 8,365
  7. Avatar for bamh 127. bamh Lv 1 3 pts. 8,359
  8. Avatar for Jim Fraser 128. Jim Fraser Lv 1 3 pts. 8,358
  9. Avatar for heterological name 129. heterological name Lv 1 3 pts. 8,348
  10. Avatar for Deleted player 130. Deleted player pts. 8,348

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 10% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Disulfide Filter: Yields a bonus of up to 1000 points for 2 or 3 disulfide bonds. More than 3 disulfides will incur penalties.