Placeholder image of a protein
Icon representing a puzzle

1002: 22 Residue Peptide Design

Closed since over 11 years ago

Intermediate Overall Design

Summary

Created
October 20, 2014
Expires
Max points
100
Description

This puzzle is aimed at designing short peptides that fold into stable structures. We encourage the use of multiple disulfide bonds, but discourage GLY residues, which will score especially poorly here. See the puzzle comments for more information about filters. The Baker lab will run folding predictions on your best designs, and the the ones that perform well will be synthesized and further validated for structural stability. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Natural Abilities 21. Natural Abilities 1 pt. 8,326
  2. Avatar for freefolder 22. freefolder 1 pt. 8,264
  3. Avatar for Eὕρηκα! Heureka! 23. Eὕρηκα! Heureka! 1 pt. 8,256
  4. Avatar for xkcd 24. xkcd 1 pt. 8,221
  5. Avatar for Czech National Team 25. Czech National Team 1 pt. 8,158
  6. Avatar for Cell Biology Fall 2014 with Smith 26. Cell Biology Fall 2014 with Smith 1 pt. 8,133
  7. Avatar for Mr. Baxley's Students 27. Mr. Baxley's Students 1 pt. 8,130
  8. Avatar for Deleted group 28. Deleted group pts. 7,857
  9. Avatar for DSN @ Home 29. DSN @ Home 1 pt. 7,784
  10. Avatar for DCC Folders 30. DCC Folders 1 pt. 7,781
  1. Avatar for wosser1 141. wosser1 Lv 1 2 pts. 8,325
  2. Avatar for ZiiONIC 142. ZiiONIC Lv 1 2 pts. 8,322
  3. Avatar for Adeleide Aurora 143. Adeleide Aurora Lv 1 2 pts. 8,322
  4. Avatar for Kaputnik 144. Kaputnik Lv 1 1 pt. 8,317
  5. Avatar for Pro Lapser 145. Pro Lapser Lv 1 1 pt. 8,317
  6. Avatar for pizpot 146. pizpot Lv 1 1 pt. 8,317
  7. Avatar for Froobyflake 147. Froobyflake Lv 1 1 pt. 8,312
  8. Avatar for tallguy-13088 148. tallguy-13088 Lv 1 1 pt. 8,308
  9. Avatar for PrettyPony2001 149. PrettyPony2001 Lv 1 1 pt. 8,307
  10. Avatar for Iron pet 150. Iron pet Lv 1 1 pt. 8,305

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 10% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Disulfide Filter: Yields a bonus of up to 1000 points for 2 or 3 disulfide bonds. More than 3 disulfides will incur penalties.