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1002: 22 Residue Peptide Design

Closed since over 11 years ago

Intermediate Overall Design

Summary

Created
October 20, 2014
Expires
Max points
100
Description

This puzzle is aimed at designing short peptides that fold into stable structures. We encourage the use of multiple disulfide bonds, but discourage GLY residues, which will score especially poorly here. See the puzzle comments for more information about filters. The Baker lab will run folding predictions on your best designs, and the the ones that perform well will be synthesized and further validated for structural stability. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

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  3. Avatar for ViJay7019 153. ViJay7019 Lv 1 1 pt. 8,299
  4. Avatar for Andi1960 154. Andi1960 Lv 1 1 pt. 8,298
  5. Avatar for Kren 155. Kren Lv 1 1 pt. 8,293
  6. Avatar for tzabaoth 156. tzabaoth Lv 1 1 pt. 8,291
  7. Avatar for poaceae 157. poaceae Lv 1 1 pt. 8,289
  8. Avatar for JasperD 158. JasperD Lv 1 1 pt. 8,280
  9. Avatar for arginia 159. arginia Lv 1 1 pt. 8,276
  10. Avatar for SHK5P 160. SHK5P Lv 1 1 pt. 8,275

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 10% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Disulfide Filter: Yields a bonus of up to 1000 points for 2 or 3 disulfide bonds. More than 3 disulfides will incur penalties.