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1002: 22 Residue Peptide Design

Closed since over 11 years ago

Intermediate Overall Design

Summary

Created
October 20, 2014
Expires
Max points
100
Description

This puzzle is aimed at designing short peptides that fold into stable structures. We encourage the use of multiple disulfide bonds, but discourage GLY residues, which will score especially poorly here. See the puzzle comments for more information about filters. The Baker lab will run folding predictions on your best designs, and the the ones that perform well will be synthesized and further validated for structural stability. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Natural Abilities 21. Natural Abilities 1 pt. 8,326
  2. Avatar for freefolder 22. freefolder 1 pt. 8,264
  3. Avatar for Eὕρηκα! Heureka! 23. Eὕρηκα! Heureka! 1 pt. 8,256
  4. Avatar for xkcd 24. xkcd 1 pt. 8,221
  5. Avatar for Czech National Team 25. Czech National Team 1 pt. 8,158
  6. Avatar for Cell Biology Fall 2014 with Smith 26. Cell Biology Fall 2014 with Smith 1 pt. 8,133
  7. Avatar for Mr. Baxley's Students 27. Mr. Baxley's Students 1 pt. 8,130
  8. Avatar for Deleted group 28. Deleted group pts. 7,857
  9. Avatar for DSN @ Home 29. DSN @ Home 1 pt. 7,784
  10. Avatar for DCC Folders 30. DCC Folders 1 pt. 7,781
  1. Avatar for 3966437 181. 3966437 Lv 1 1 pt. 8,124
  2. Avatar for SzalonyMajster 182. SzalonyMajster Lv 1 1 pt. 8,067
  3. Avatar for frezae 183. frezae Lv 1 1 pt. 8,037
  4. Avatar for Mengee 184. Mengee Lv 1 1 pt. 8,036
  5. Avatar for sinoue99 185. sinoue99 Lv 1 1 pt. 8,014
  6. Avatar for Puttering 186. Puttering Lv 1 1 pt. 8,013
  7. Avatar for Cerzax 187. Cerzax Lv 1 1 pt. 8,010
  8. Avatar for rinze 188. rinze Lv 1 1 pt. 7,981
  9. Avatar for The Mad Fool 189. The Mad Fool Lv 1 1 pt. 7,940
  10. Avatar for Ashrai 190. Ashrai Lv 1 1 pt. 7,930

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 10% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Disulfide Filter: Yields a bonus of up to 1000 points for 2 or 3 disulfide bonds. More than 3 disulfides will incur penalties.