1002: 22 Residue Peptide Design

Closed since over 11 years ago

Summary

• Created: October 20, 2014
• Expires: October 29, 2014 at 23:00 UTC
• Max points: 100

Description

This puzzle is aimed at designing short peptides that fold into stable structures. We encourage the use of multiple disulfide bonds, but discourage GLY residues, which will score especially poorly here. See the puzzle comments for more information about filters. The Baker lab will run folding predictions on your best designs, and the the ones that perform well will be synthesized and further validated for structural stability. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

• 1. Gargleblasters 100 pts. 9,516
• 2. Beta Folders 84 pts. 9,499
• 3. Go Science 70 pts. 9,494
• 4. Deleted group pts. 9,491
• 5. Anthropic Dreams 48 pts. 9,484
• 6. L'Alliance Francophone 39 pts. 9,450
• 7. Void Crushers 32 pts. 9,430
• 8. Contenders 26 pts. 9,423
• 9. SETI.Germany 20 pts. 9,333
• 10. Russian team 16 pts. 9,302

Top evolvers

• 1. Orcus 100 pts. 9,516
• 2. Skippysk8s 86 pts. 9,515
• 3. Zuqq 74 pts. 9,514
• 4. Ashrai 63 pts. 9,507
• 5. frood66 53 pts. 9,506
• 6. Googol30 44 pts. 9,503
• 7. Blipperman 37 pts. 9,501
• 8. ManVsYard 31 pts. 9,501
• 9. LociOiling 25 pts. 9,499
• 10. retiredmichael 21 pts. 9,497

Comments

[bkoep]

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 10% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Disulfide Filter: Yields a bonus of up to 1000 points for 2 or 3 disulfide bonds. More than 3 disulfides will incur penalties.