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1002: 22 Residue Peptide Design

Closed since over 11 years ago

Intermediate Overall Design

Summary

Created
October 20, 2014
Expires
Max points
100
Description

This puzzle is aimed at designing short peptides that fold into stable structures. We encourage the use of multiple disulfide bonds, but discourage GLY residues, which will score especially poorly here. See the puzzle comments for more information about filters. The Baker lab will run folding predictions on your best designs, and the the ones that perform well will be synthesized and further validated for structural stability. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Gargleblasters
    1. Gargleblasters
    100 pts. 9,516
  2. Avatar for Beta Folders 2. Beta Folders 84 pts. 9,499
  3. Avatar for Go Science 3. Go Science 70 pts. 9,494
  4. Avatar for Deleted group 4. Deleted group pts. 9,491
  5. Avatar for Anthropic Dreams 5. Anthropic Dreams 48 pts. 9,484
  6. Avatar for L'Alliance Francophone 6. L'Alliance Francophone 39 pts. 9,450
  7. Avatar for Void Crushers 7. Void Crushers 32 pts. 9,430
  8. Avatar for Contenders 8. Contenders 26 pts. 9,423
  9. Avatar for SETI.Germany 9. SETI.Germany 20 pts. 9,333
  10. Avatar for Russian team 10. Russian team 16 pts. 9,302
  1. Avatar for kkhater 201. kkhater Lv 1 1 pt. 7,857
  2. Avatar for crawlee34225 202. crawlee34225 Lv 1 1 pt. 7,850
  3. Avatar for azak2002 203. azak2002 Lv 1 1 pt. 7,849
  4. Avatar for skyscout 204. skyscout Lv 1 1 pt. 7,838
  5. Avatar for Darksteve 205. Darksteve Lv 1 1 pt. 7,816
  6. Avatar for rlee287 206. rlee287 Lv 1 1 pt. 7,810
  7. Avatar for Auntiesocial 207. Auntiesocial Lv 1 1 pt. 7,787
  8. Avatar for aspadistra 208. aspadistra Lv 1 1 pt. 7,784
  9. Avatar for jstoddard 209. jstoddard Lv 1 1 pt. 7,781
  10. Avatar for gauravb 210. gauravb Lv 1 1 pt. 7,573

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 10% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Disulfide Filter: Yields a bonus of up to 1000 points for 2 or 3 disulfide bonds. More than 3 disulfides will incur penalties.