Placeholder image of a protein
Icon representing a puzzle

1017: 85 Residue Monomer Design: More Sheets!

Closed since over 11 years ago

Intermediate Overall Design

Summary

Created
November 21, 2014
Expires
Max points
100
Description

This puzzle uses the updated Core Existence filter, and has a slightly lower threshold for identifying "core" residues. Click the "Show" checkbox beneath the Core Existence filter to see which residues have been identified as Core (orange), Boundary (green), or Surface (blue). There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Eὕρηκα! Heureka! 21. Eὕρηκα! Heureka! 1 pt. 2,806
  2. Avatar for Repro-men 22. Repro-men 1 pt. 2,096
  3. Avatar for Oma Gawd 23. Oma Gawd 1 pt. 2,082
  4. Avatar for DSN @ Home 24. DSN @ Home 1 pt. 1,812
  5. Avatar for Deleted group 25. Deleted group pts. 1,407
  6. Avatar for Shake and Wiggle FTW 26. Shake and Wiggle FTW 1 pt. 0
  7. Avatar for It's over 9000! 27. It's over 9000! 1 pt. 0
  8. Avatar for Biochemistry Bonus Marks 28. Biochemistry Bonus Marks 1 pt. 0
  9. Avatar for TH2014 29. TH2014 1 pt. 0
  10. Avatar for Piratenpartei Deutschland 30. Piratenpartei Deutschland 1 pt. 0
  1. Avatar for grogar7 11. grogar7 Lv 1 84 pts. 10,335
  2. Avatar for Hiro Protagonist 12. Hiro Protagonist Lv 1 82 pts. 10,325
  3. Avatar for nicobul 13. nicobul Lv 1 81 pts. 10,325
  4. Avatar for LociOiling 14. LociOiling Lv 1 79 pts. 10,315
  5. Avatar for Susume 15. Susume Lv 1 78 pts. 10,305
  6. Avatar for spmm 16. spmm Lv 1 77 pts. 10,298
  7. Avatar for frood66 17. frood66 Lv 1 75 pts. 10,273
  8. Avatar for Bautho 18. Bautho Lv 1 74 pts. 10,271
  9. Avatar for crpainter 19. crpainter Lv 1 72 pts. 10,262
  10. Avatar for bertro 20. bertro Lv 1 71 pts. 10,175

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that at least 50% of residues are in sheets; penalties are incurred if fewer than 50% of residues form sheets.

Secondary Structure Design: Penalizes GLY, ALA, and PRO residues in helices and sheets.

Bruno Kestemont Lv 1

Or may be, we receive a bonus for any condition 100 % met (enough sheets would receive 150 pts, core +160, Secundary Structure +500