Placeholder image of a protein
Icon representing a puzzle

1017: 85 Residue Monomer Design: More Sheets!

Closed since over 11 years ago

Intermediate Overall Design

Summary

Created
November 21, 2014
Expires
Max points
100
Description

This puzzle uses the updated Core Existence filter, and has a slightly lower threshold for identifying "core" residues. Click the "Show" checkbox beneath the Core Existence filter to see which residues have been identified as Core (orange), Boundary (green), or Surface (blue). There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Deleted group 31. Deleted group pts. 0
  1. Avatar for Pro Lapser 131. Pro Lapser Lv 1 5 pts. 4,328
  2. Avatar for PrettyPony2001 132. PrettyPony2001 Lv 1 5 pts. 4,324
  3. Avatar for persephone977 133. persephone977 Lv 1 5 pts. 4,311
  4. Avatar for Zilluban 134. Zilluban Lv 1 5 pts. 4,311
  5. Avatar for erikviking 135. erikviking Lv 1 4 pts. 4,308
  6. Avatar for machinelves 136. machinelves Lv 1 4 pts. 4,299
  7. Avatar for sgfronza 137. sgfronza Lv 1 4 pts. 4,275
  8. Avatar for Maru67 138. Maru67 Lv 1 4 pts. 4,263
  9. Avatar for fryguy 139. fryguy Lv 1 4 pts. 4,218
  10. Avatar for bcd 140. bcd Lv 1 4 pts. 4,205

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that at least 50% of residues are in sheets; penalties are incurred if fewer than 50% of residues form sheets.

Secondary Structure Design: Penalizes GLY, ALA, and PRO residues in helices and sheets.

Bruno Kestemont Lv 1

Or may be, we receive a bonus for any condition 100 % met (enough sheets would receive 150 pts, core +160, Secundary Structure +500