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1018b: 65 Residue Symmetric Trimer Design

Closed since over 11 years ago

Intermediate Overall Design Symmetry

Summary

Created
November 25, 2014
Expires
Max points
100
Description

It's been a long time since our last Symmetric Design puzzle, and Foldit has seen a lot of improvements in the mean time! This puzzle uses two "Core Existence" filters. One checks that the monomer unit of your design contains a well-packed core, and another ensures that the entire symmetric complex has a buried core. Click the "Show" checkbox beneath the Core Existence filter to see which residues have been identified as Core (orange), Boundary (green), or Surface (blue). There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

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Comments

jflat06 Staff Lv 1

You can access your old saves from the new puzzle's load-save dialog.

You can also access the old puzzle by clicking show expired puzzles in the puzzle list menu.

retiredmichael Lv 1

wondering if more flexibility was allowed in how the monomers were fit together might allow us a greater range of choices.

so symmetry at the monomer level flexibility at the
complex level

this might allow us to move on from ending up with close packed helixes