Placeholder image of a protein
Icon representing a puzzle

1024: 75 Residue Monomer Design: Zero Cysteines

Closed since over 11 years ago

Intermediate Overall Design

Summary

Created
December 11, 2014
Expires
Max points
100
Description

In this puzzle, we're asking players to design a protein with no cysteine residues! Remember that the SS Design filter now considers the environment around each residue, in addition to secondary structure. This means that some residue types will be restricted depending on whether the position is in the core or surface of the protein. There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for LS Pro Folders 21. LS Pro Folders 1 pt. 7,540
  2. Avatar for freefolder 22. freefolder 1 pt. 6,648
  3. Avatar for Geekdo 23. Geekdo 1 pt. 6,056
  4. Avatar for DSN @ Home 24. DSN @ Home 1 pt. 728
  5. Avatar for Woodlawn 7th Grade 2014-2015 25. Woodlawn 7th Grade 2014-2015 1 pt. 0
  6. Avatar for Richard Dawkins Foundation 26. Richard Dawkins Foundation 1 pt. 0
  7. Avatar for It's over 9000! 27. It's over 9000! 1 pt. 0
  8. Avatar for Window Group 28. Window Group 1 pt. 0
  1. Avatar for Devreugkx 151. Devreugkx Lv 1 1 pt. 7,540
  2. Avatar for jogie62 152. jogie62 Lv 1 1 pt. 7,526
  3. Avatar for emdee314 153. emdee314 Lv 1 1 pt. 7,520
  4. Avatar for perrystaff 154. perrystaff Lv 1 1 pt. 7,515
  5. Avatar for MUD2MMO 155. MUD2MMO Lv 1 1 pt. 7,473
  6. Avatar for persephone977 156. persephone977 Lv 1 1 pt. 7,465
  7. Avatar for pepere 157. pepere Lv 1 1 pt. 7,411
  8. Avatar for Gifted 158. Gifted Lv 1 1 pt. 7,359
  9. Avatar for Deleted player 159. Deleted player pts. 7,352
  10. Avatar for sakotsu 160. sakotsu Lv 1 1 pt. 7,352

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.

bkoep Staff Lv 1

You mean, modify the mutate function so it adheres to filter rules?

Sometimes the Mutate function does make a mutation that causes a filter to fail; I agree this behavior is undesired and also inefficient. This fix is high on the to-do list, and hopefully will be added soon.