Placeholder image of a protein
Icon representing a puzzle

1024: 75 Residue Monomer Design: Zero Cysteines

Closed since about 11 years ago

Intermediate Overall Design

Summary

Created
December 11, 2014
Expires
Max points
100
Description

In this puzzle, we're asking players to design a protein with no cysteine residues! Remember that the SS Design filter now considers the environment around each residue, in addition to secondary structure. This means that some residue types will be restricted depending on whether the position is in the core or surface of the protein. There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Anthropic Dreams
    1. Anthropic Dreams
    100 pts. 10,405
  2. Avatar for Go Science 2. Go Science 83 pts. 10,327
  3. Avatar for Void Crushers 3. Void Crushers 69 pts. 10,290
  4. Avatar for Gargleblasters 4. Gargleblasters 56 pts. 10,283
  5. Avatar for L'Alliance Francophone 5. L'Alliance Francophone 45 pts. 10,221
  6. Avatar for Beta Folders 6. Beta Folders 36 pts. 10,220
  7. Avatar for Contenders 7. Contenders 29 pts. 10,021
  8. Avatar for Deleted group 8. Deleted group pts. 9,988
  9. Avatar for FoldIt@Netherlands 9. FoldIt@Netherlands 18 pts. 9,965
  10. Avatar for HMT heritage 10. HMT heritage 14 pts. 9,939
  1. Avatar for dcrwheeler 31. dcrwheeler Lv 1 50 pts. 9,907
  2. Avatar for reefyrob 32. reefyrob Lv 1 49 pts. 9,904
  3. Avatar for g_b 33. g_b Lv 1 48 pts. 9,894
  4. Avatar for gitwut 34. gitwut Lv 1 47 pts. 9,874
  5. Avatar for Anfinsen_slept_here 35. Anfinsen_slept_here Lv 1 45 pts. 9,868
  6. Avatar for Vredeman 36. Vredeman Lv 1 44 pts. 9,842
  7. Avatar for mimi 37. mimi Lv 1 43 pts. 9,828
  8. Avatar for Sissue 38. Sissue Lv 1 42 pts. 9,826
  9. Avatar for pvc78 39. pvc78 Lv 1 41 pts. 9,822
  10. Avatar for TomTaylor 40. TomTaylor Lv 1 40 pts. 9,761

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.

bkoep Staff Lv 1

You mean, modify the mutate function so it adheres to filter rules?

Sometimes the Mutate function does make a mutation that causes a filter to fail; I agree this behavior is undesired and also inefficient. This fix is high on the to-do list, and hopefully will be added soon.