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1027b: 80 Residue Symmetric Tetramer Design

Closed since about 11 years ago

Intermediate Overall Design Symmetry

Summary

Created
December 19, 2014
Expires
Max points
100
Description

This puzzle again uses separate "Core Existence" filters for the monomer unit and the symmetric complex. Click the "Show" checkbox beneath the Core Existence filter to see which residues have been identified as Core (orange), Boundary (green), or Surface (blue). There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!




This puzzle will be online for two and half weeks, so take the opportunity to try several different designs!

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Comments

Norrjane Lv 1

I can certain appreciate that. And I hope you don't think I was looking for 'the answer'. It's easy as a beginner to get frustrated and feel that some how you missed out on a second group of tutorials, or instruction booklet or something, when you work for several days and can't get up to 0!
Or to feel that you just 'don't have it' and should give up.
Thank you for the video and I very much look forward to the learning process!
Take care,
Jane

Bruno Kestemont Lv 1

With the button disable slow filter, you gain a lot of time.

Porky just released many recipes dealing with this, in the public recipes. Great for this kind of puzzle.

Skippysk8s Lv 1

This puzzle jams up the log file, which slows it down even more. Is there a way to fix this? My group has found we have to shut the client down and restart regularly to limit the problem, but since programs can take 12-15 hours to run on our ordinary computers this can be hard.
This fix might make me willing to do one of these again. I feel like I am losing due to machine speed…. kind of a bummer
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