Placeholder image of a protein
Icon representing a puzzle

1037: 50 Residue Symmetric Pentamer Design

Closed since about 11 years ago

Intermediate Overall Design

Summary

Created
January 14, 2015
Expires
Max points
100
Description

This puzzle again uses separate "Core Existence" filters for the monomer unit and the symmetric complex. Click the "Show" checkbox beneath the Core Existence filter to see which residues have been identified as Core (orange), Boundary (green), or Surface (blue). There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Beta Folders
    1. Beta Folders
    100 pts. 11,525
  2. Avatar for Anthropic Dreams 2. Anthropic Dreams 83 pts. 11,415
  3. Avatar for Go Science 3. Go Science 69 pts. 11,387
  4. Avatar for Void Crushers 4. Void Crushers 56 pts. 11,359
  5. Avatar for Deleted group 5. Deleted group pts. 11,341
  6. Avatar for Deleted group 6. Deleted group pts. 11,278
  7. Avatar for L'Alliance Francophone 7. L'Alliance Francophone 29 pts. 11,215
  8. Avatar for Contenders 8. Contenders 23 pts. 11,100
  9. Avatar for HMT heritage 9. HMT heritage 18 pts. 11,017
  10. Avatar for SETI.Germany 10. SETI.Germany 14 pts. 10,889
  1. Avatar for TomTaylor 11. TomTaylor Lv 1 79 pts. 11,252
  2. Avatar for hpaege 12. hpaege Lv 1 77 pts. 11,231
  3. Avatar for Anfinsen_slept_here 13. Anfinsen_slept_here Lv 1 75 pts. 11,229
  4. Avatar for BitSpawn 14. BitSpawn Lv 1 73 pts. 11,219
  5. Avatar for Galaxie 15. Galaxie Lv 1 71 pts. 11,215
  6. Avatar for Museka 16. Museka Lv 1 69 pts. 11,215
  7. Avatar for bertro 17. bertro Lv 1 67 pts. 11,184
  8. Avatar for viosca 18. viosca Lv 1 66 pts. 11,180
  9. Avatar for christioanchauvin 19. christioanchauvin Lv 1 64 pts. 11,166
  10. Avatar for LociOiling 20. LociOiling Lv 1 62 pts. 11,163

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Monomer: Ensures that at least 20% of the residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 35% of the residues are buried in the core of the entire complex (including the interface between monomer units).

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure Design: Penalizes GLY, ALA, and PRO residues in helices and sheets.

bkoep Staff Lv 1

In general, Foldit score does increase with the number of residues in a design, but "symmetric residues" do not contribute in this case. We expect designs in this puzzle to score similarly to a 50 residue monomer, with the addition of the interface points for a single monomer subunit.

Bruno Kestemont Lv 1

I found the formula was like 8000 + net filters+ about [13-25] * monomer number of residues * symmetry

That would make a potential of about
11720 to 14720 pts for this one

11523 seems quite low indeed, but I think it's much more difficult to get higher scores with the many conditions that are present now.

(In the past, you had more freedom to find unrealistic high scoring solutions).