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1040: 65 Residue Monomer Design: Zero Cysteines

Closed since about 11 years ago

Intermediate Overall Design

Summary

Created
January 21, 2015
Expires
Max points
100
Description

In this puzzle, we're asking players to design a protein with no cysteine residues! Remember that the SS Design filter now considers the environment around each residue, in addition to secondary structure. This means that some residue types will be restricted depending on whether the position is in the core or surface of the protein. There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Crunching Family 21. Crunching Family 1 pt. 7,690
  2. Avatar for It's over 9000! 22. It's over 9000! 1 pt. 7,544
  3. Avatar for Deleted group 23. Deleted group pts. 7,452
  4. Avatar for DSN @ Home 24. DSN @ Home 1 pt. 7,445
  5. Avatar for Geekdo 25. Geekdo 1 pt. 0
  1. Avatar for Donobit 101. Donobit Lv 1 4 pts. 8,360
  2. Avatar for jobo0502 102. jobo0502 Lv 1 4 pts. 8,353
  3. Avatar for Fowardint 103. Fowardint Lv 1 4 pts. 8,352
  4. Avatar for SHK5P 104. SHK5P Lv 1 4 pts. 8,325
  5. Avatar for csantanna 105. csantanna Lv 1 4 pts. 8,236
  6. Avatar for sakotsu 106. sakotsu Lv 1 3 pts. 8,221
  7. Avatar for multaq 107. multaq Lv 1 3 pts. 8,219
  8. Avatar for harp 108. harp Lv 1 3 pts. 8,208
  9. Avatar for mirjamvandelft 109. mirjamvandelft Lv 1 3 pts. 8,206
  10. Avatar for bamh 110. bamh Lv 1 3 pts. 8,205

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 25% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.