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1040: 65 Residue Monomer Design: Zero Cysteines

Closed since about 11 years ago

Intermediate Overall Design

Summary

Created
January 21, 2015
Expires
Max points
100
Description

In this puzzle, we're asking players to design a protein with no cysteine residues! Remember that the SS Design filter now considers the environment around each residue, in addition to secondary structure. This means that some residue types will be restricted depending on whether the position is in the core or surface of the protein. There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Crunching Family 21. Crunching Family 1 pt. 7,690
  2. Avatar for It's over 9000! 22. It's over 9000! 1 pt. 7,544
  3. Avatar for Deleted group 23. Deleted group pts. 7,452
  4. Avatar for DSN @ Home 24. DSN @ Home 1 pt. 7,445
  5. Avatar for Geekdo 25. Geekdo 1 pt. 0
  1. Avatar for phi16 141. phi16 Lv 1 1 pt. 7,589
  2. Avatar for bcd 142. bcd Lv 1 1 pt. 7,564
  3. Avatar for persephone977 143. persephone977 Lv 1 1 pt. 7,553
  4. Avatar for BCAA 144. BCAA Lv 1 1 pt. 7,544
  5. Avatar for puxatudo 145. puxatudo Lv 1 1 pt. 7,542
  6. Avatar for WBarme1234 146. WBarme1234 Lv 1 1 pt. 7,495
  7. Avatar for NotJim99 147. NotJim99 Lv 1 1 pt. 7,479
  8. Avatar for uhuuhu 148. uhuuhu Lv 1 1 pt. 7,460
  9. Avatar for AryehK 149. AryehK Lv 1 1 pt. 7,456
  10. Avatar for gameupshark 150. gameupshark Lv 1 1 pt. 7,455

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 25% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.