Placeholder image of a protein
Icon representing a puzzle

1043: 55 Residue Symmetric Hexamer Design

Closed since about 11 years ago

Intermediate Overall Design Symmetry

Summary

Created
January 28, 2015
Expires
Max points
100
Description

This puzzle again uses separate "Core Existence" filters for the monomer unit and the symmetric complex. Click the "Show" checkbox beneath the Core Existence filter to see which residues have been identified as Core (orange), Boundary (green), or Surface (blue). There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Go Science
    1. Go Science
    100 pts. 11,918
  2. Avatar for Beta Folders 2. Beta Folders 85 pts. 11,884
  3. Avatar for Anthropic Dreams 3. Anthropic Dreams 71 pts. 11,736
  4. Avatar for L'Alliance Francophone 4. L'Alliance Francophone 60 pts. 11,719
  5. Avatar for Void Crushers 5. Void Crushers 49 pts. 11,647
  6. Avatar for Deleted group 6. Deleted group pts. 11,605
  7. Avatar for Gargleblasters 7. Gargleblasters 33 pts. 11,407
  8. Avatar for Deleted group 8. Deleted group pts. 11,352
  9. Avatar for Contenders 9. Contenders 22 pts. 11,116
  10. Avatar for HMT heritage 10. HMT heritage 17 pts. 11,082
  1. Avatar for oldrobinwood 231. oldrobinwood Lv 1 1 pt. 0
  2. Avatar for matosfran 232. matosfran Lv 1 1 pt. 0
  3. Avatar for jebbiek 233. jebbiek Lv 1 1 pt. 0
  4. Avatar for FishKAA 234. FishKAA Lv 1 1 pt. 0
  5. Avatar for casprus 235. casprus Lv 1 1 pt. 0
  6. Avatar for harvardman 236. harvardman Lv 1 1 pt. 0
  7. Avatar for Space Goat 237. Space Goat Lv 1 1 pt. 0
  8. Avatar for matollik 238. matollik Lv 1 1 pt. 0
  9. Avatar for Origami314 239. Origami314 Lv 1 1 pt. 0
  10. Avatar for Maru67 240. Maru67 Lv 1 1 pt. 0

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Monomer: Ensures that at least 20% of the residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 35% of the residues are buried in the core of the entire complex (including the interface between monomer units).

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure Design: Penalizes GLY, ALA, and PRO residues in helices and sheets.

alwen Lv 1

Folding this one is like pushing a tank with my forehead.

Stopping a wiggle takes 20 seconds. I timed it! Twenty seconds from clicking Stop to actually stopping.