Placeholder image of a protein
Icon representing a puzzle

1046: Player-Solution Strand Redesign

Closed since about 11 years ago

Intermediate Overall Design

Summary

Created
February 04, 2015
Expires
Max points
100
Description

This is a puzzle where you can redesign part of a player-designed protein. This is a monomer designed by viosca for Puzzle 1024: 75 Residue Monomer Design: Zero Cysteines. Our analysis shows that most of this protein is likely to fold, but that the first strand and loop can adopt some alternative conformations. Help us redesign this region of the protein to lock down the position of the first strand! Players may make mutations only at certain positions that contact the first strand. Players may also insert two additional residues in this region, but beware that changing the shape of the protein too much will disqualify your design!

Top groups

  1. Avatar for Italiani Al Lavoro 11. Italiani Al Lavoro 13 pts. 9,786
  2. Avatar for HMT heritage 12. HMT heritage 10 pts. 9,773
  3. Avatar for Russian team 13. Russian team 7 pts. 9,771
  4. Avatar for xkcd 14. xkcd 6 pts. 9,771
  5. Avatar for Team Schleswig-Holstein 15. Team Schleswig-Holstein 4 pts. 9,769
  6. Avatar for Eὕρηκα! Heureka! 16. Eὕρηκα! Heureka! 3 pts. 9,768
  7. Avatar for Chem233W15 17. Chem233W15 2 pts. 9,767
  8. Avatar for FoldIt@Netherlands 18. FoldIt@Netherlands 2 pts. 9,767
  9. Avatar for Natural Abilities 19. Natural Abilities 1 pt. 9,767
  10. Avatar for Ukraine 20. Ukraine 1 pt. 9,766
  1. Avatar for franse 141. franse Lv 1 3 pts. 9,766
  2. Avatar for LagMasterSam 142. LagMasterSam Lv 1 3 pts. 9,766
  3. Avatar for Merf 143. Merf Lv 1 3 pts. 9,766
  4. Avatar for tornado163 144. tornado163 Lv 1 2 pts. 9,766
  5. Avatar for puxatudo 145. puxatudo Lv 1 2 pts. 9,766
  6. Avatar for miskof 146. miskof Lv 1 2 pts. 9,766
  7. Avatar for kouen 147. kouen Lv 1 1 pt. 9,766
  8. Avatar for Cmillertime 148. Cmillertime Lv 1 1 pt. 9,766
  9. Avatar for maninas 149. maninas Lv 1 1 pt. 9,766
  10. Avatar for roma2907 150. roma2907 Lv 1 2 pts. 9,766

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.

Exploration: Designs that deviate from the starting structure with RMSD > 2.0Å are invalid.

brow42 Lv 1

First thing I did was shift the first helix 1 segment. This alone brought me up to 1.90 exploration. I think the loop on one end is too short. But if I can't shift it, I don't have much room to move.