Placeholder image of a protein
Icon representing a puzzle

1048: 26 Residue Peptide Design

Closed since about 11 years ago

Intermediate Overall Design

Summary

Created
February 05, 2015
Expires
Max points
100
Description

This puzzle is aimed at designing short peptides that fold into stable structures. We encourage the use of multiple disulfide bonds, but discourage GLY residues, which will score especially poorly here. See the puzzle comments for more information about filters. The Baker lab will run folding predictions on your best designs, and the the ones that perform well will be synthesized and further validated for structural stability. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for It's over 9000! 11. It's over 9000! 13 pts. 9,473
  2. Avatar for Italiani Al Lavoro 12. Italiani Al Lavoro 10 pts. 9,253
  3. Avatar for HMT heritage 13. HMT heritage 7 pts. 8,978
  4. Avatar for Deleted group 14. Deleted group pts. 8,608
  5. Avatar for Natural Abilities 15. Natural Abilities 4 pts. 8,543
  6. Avatar for Team Schleswig-Holstein 16. Team Schleswig-Holstein 3 pts. 8,472
  7. Avatar for xkcd 17. xkcd 2 pts. 8,439
  8. Avatar for Chem233W15 18. Chem233W15 2 pts. 8,436
  9. Avatar for freefolder 19. freefolder 1 pt. 8,422
  10. Avatar for CHNO Junkies 20. CHNO Junkies 1 pt. 8,394
  1. Avatar for Sadler 151. Sadler Lv 1 3 pts. 8,323
  2. Avatar for froggs554 152. froggs554 Lv 1 2 pts. 8,322
  3. Avatar for mariahjo 153. mariahjo Lv 1 2 pts. 8,321
  4. Avatar for SouperGenious 154. SouperGenious Lv 1 2 pts. 8,317
  5. Avatar for sansyo 155. sansyo Lv 1 2 pts. 8,314
  6. Avatar for dahast.de 156. dahast.de Lv 1 2 pts. 8,313
  7. Avatar for juram2015 157. juram2015 Lv 1 2 pts. 8,309
  8. Avatar for Savas 158. Savas Lv 1 2 pts. 8,301
  9. Avatar for dankey_kang 159. dankey_kang Lv 1 2 pts. 8,301
  10. Avatar for Paltiel 160. Paltiel Lv 1 2 pts. 8,294

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 10% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Disulfide Filter: Yields a bonus of up to 1000 points for 2 or 3 disulfide bonds. More than 3 disulfides will incur penalties.