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1048: 26 Residue Peptide Design

Closed since about 11 years ago

Intermediate Overall Design

Summary

Created
February 05, 2015
Expires
Max points
100
Description

This puzzle is aimed at designing short peptides that fold into stable structures. We encourage the use of multiple disulfide bonds, but discourage GLY residues, which will score especially poorly here. See the puzzle comments for more information about filters. The Baker lab will run folding predictions on your best designs, and the the ones that perform well will be synthesized and further validated for structural stability. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

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  1. Avatar for It's over 9000! 11. It's over 9000! 13 pts. 9,473
  2. Avatar for Italiani Al Lavoro 12. Italiani Al Lavoro 10 pts. 9,253
  3. Avatar for HMT heritage 13. HMT heritage 7 pts. 8,978
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  6. Avatar for Team Schleswig-Holstein 16. Team Schleswig-Holstein 3 pts. 8,472
  7. Avatar for xkcd 17. xkcd 2 pts. 8,439
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  1. Avatar for LagMasterSam 191. LagMasterSam Lv 1 1 pt. 7,824
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  3. Avatar for jack83829 193. jack83829 Lv 1 1 pt. 7,797
  4. Avatar for rahulroy94 194. rahulroy94 Lv 1 1 pt. 7,782
  5. Avatar for pandabearsecond 195. pandabearsecond Lv 1 1 pt. 7,781
  6. Avatar for Hau5ratz 196. Hau5ratz Lv 1 1 pt. 7,768
  7. Avatar for elykl33t 197. elykl33t Lv 1 1 pt. 7,757
  8. Avatar for leehaggis 198. leehaggis Lv 1 1 pt. 7,735
  9. Avatar for jogie62 199. jogie62 Lv 1 1 pt. 7,720
  10. Avatar for NotJim99 200. NotJim99 Lv 1 1 pt. 7,710

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 10% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Disulfide Filter: Yields a bonus of up to 1000 points for 2 or 3 disulfide bonds. More than 3 disulfides will incur penalties.