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1048: 26 Residue Peptide Design

Closed since about 11 years ago

Intermediate Overall Design

Summary

Created
February 05, 2015
Expires
Max points
100
Description

This puzzle is aimed at designing short peptides that fold into stable structures. We encourage the use of multiple disulfide bonds, but discourage GLY residues, which will score especially poorly here. See the puzzle comments for more information about filters. The Baker lab will run folding predictions on your best designs, and the the ones that perform well will be synthesized and further validated for structural stability. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

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  2. Avatar for Italiani Al Lavoro 12. Italiani Al Lavoro 10 pts. 9,253
  3. Avatar for HMT heritage 13. HMT heritage 7 pts. 8,978
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  7. Avatar for xkcd 17. xkcd 2 pts. 8,439
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  1. Avatar for sand4839 211. sand4839 Lv 1 1 pt. 6,908
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  3. Avatar for MadTrumpeter 213. MadTrumpeter Lv 1 1 pt. 6,712
  4. Avatar for rodsouza99 214. rodsouza99 Lv 1 1 pt. 6,591
  5. Avatar for LeninLives 215. LeninLives Lv 1 1 pt. 6,587
  6. Avatar for virtuose9721 216. virtuose9721 Lv 1 1 pt. 6,521
  7. Avatar for jds11235 217. jds11235 Lv 1 1 pt. 6,451
  8. Avatar for DC342_2015aacook 218. DC342_2015aacook Lv 1 1 pt. 6,447
  9. Avatar for M4414 219. M4414 Lv 1 1 pt. 6,434
  10. Avatar for kyle.winkler 220. kyle.winkler Lv 1 1 pt. 6,397

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 10% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Disulfide Filter: Yields a bonus of up to 1000 points for 2 or 3 disulfide bonds. More than 3 disulfides will incur penalties.