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1048: 26 Residue Peptide Design

Closed since about 11 years ago

Intermediate Overall Design

Summary

Created
February 05, 2015
Expires
Max points
100
Description

This puzzle is aimed at designing short peptides that fold into stable structures. We encourage the use of multiple disulfide bonds, but discourage GLY residues, which will score especially poorly here. See the puzzle comments for more information about filters. The Baker lab will run folding predictions on your best designs, and the the ones that perform well will be synthesized and further validated for structural stability. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

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  1. Avatar for johnmitch 21. johnmitch Lv 1 69 pts. 9,539
  2. Avatar for Timo van der Laan 22. Timo van der Laan Lv 1 68 pts. 9,537
  3. Avatar for stomjoh 23. stomjoh Lv 1 67 pts. 9,529
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  5. Avatar for eusair 25. eusair Lv 1 64 pts. 9,523
  6. Avatar for spmm 26. spmm Lv 1 63 pts. 9,521
  7. Avatar for pvc78 27. pvc78 Lv 1 62 pts. 9,515
  8. Avatar for pauldunn 28. pauldunn Lv 1 60 pts. 9,512
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  10. Avatar for Mike Cassidy 30. Mike Cassidy Lv 1 58 pts. 9,510

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 10% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Disulfide Filter: Yields a bonus of up to 1000 points for 2 or 3 disulfide bonds. More than 3 disulfides will incur penalties.