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1048: 26 Residue Peptide Design

Closed since about 11 years ago

Intermediate Overall Design

Summary

Created
February 05, 2015
Expires
Max points
100
Description

This puzzle is aimed at designing short peptides that fold into stable structures. We encourage the use of multiple disulfide bonds, but discourage GLY residues, which will score especially poorly here. See the puzzle comments for more information about filters. The Baker lab will run folding predictions on your best designs, and the the ones that perform well will be synthesized and further validated for structural stability. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Russian team 21. Russian team 1 pt. 8,349
  2. Avatar for StructuralBiology-CHEM490 22. StructuralBiology-CHEM490 1 pt. 8,309
  3. Avatar for Eὕρηκα! Heureka! 23. Eὕρηκα! Heureka! 1 pt. 8,301
  4. Avatar for FoldIt@Netherlands 24. FoldIt@Netherlands 1 pt. 8,288
  5. Avatar for Deleted group 25. Deleted group pts. 7,434
  6. Avatar for CS3824F14 26. CS3824F14 1 pt. 6,294
  7. Avatar for test_group1 27. test_group1 1 pt. 6,289
  8. Avatar for DSN @ Home 28. DSN @ Home 1 pt. 6,239
  9. Avatar for pROO-TEENS 29. pROO-TEENS 1 pt. 6,238
  10. Avatar for Window Group 30. Window Group 1 pt. 6,228
  1. Avatar for test_account2 241. test_account2 Lv 1 1 pt. 6,228
  2. Avatar for test_account1 242. test_account1 Lv 1 1 pt. 6,228
  3. Avatar for jackcr 243. jackcr Lv 1 1 pt. 6,228
  4. Avatar for bavent 244. bavent Lv 1 1 pt. 6,005
  5. Avatar for carmen_thought_of_my_name 245. carmen_thought_of_my_name Lv 1 1 pt. 5,885
  6. Avatar for danielahaber 246. danielahaber Lv 1 1 pt. 5,723
  7. Avatar for Sydefecks 247. Sydefecks Lv 1 1 pt. 5,693
  8. Avatar for t3a3r3n 248. t3a3r3n Lv 1 1 pt. 5,443
  9. Avatar for TSOTD 249. TSOTD Lv 1 1 pt. 5,021
  10. Avatar for helix415 250. helix415 Lv 1 1 pt. 4,326

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 10% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Disulfide Filter: Yields a bonus of up to 1000 points for 2 or 3 disulfide bonds. More than 3 disulfides will incur penalties.