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1048: 26 Residue Peptide Design

Closed since about 11 years ago

Intermediate Overall Design

Summary

Created
February 05, 2015
Expires
Max points
100
Description

This puzzle is aimed at designing short peptides that fold into stable structures. We encourage the use of multiple disulfide bonds, but discourage GLY residues, which will score especially poorly here. See the puzzle comments for more information about filters. The Baker lab will run folding predictions on your best designs, and the the ones that perform well will be synthesized and further validated for structural stability. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Russian team 21. Russian team 1 pt. 8,349
  2. Avatar for StructuralBiology-CHEM490 22. StructuralBiology-CHEM490 1 pt. 8,309
  3. Avatar for Eὕρηκα! Heureka! 23. Eὕρηκα! Heureka! 1 pt. 8,301
  4. Avatar for FoldIt@Netherlands 24. FoldIt@Netherlands 1 pt. 8,288
  5. Avatar for Deleted group 25. Deleted group pts. 7,434
  6. Avatar for CS3824F14 26. CS3824F14 1 pt. 6,294
  7. Avatar for test_group1 27. test_group1 1 pt. 6,289
  8. Avatar for DSN @ Home 28. DSN @ Home 1 pt. 6,239
  9. Avatar for pROO-TEENS 29. pROO-TEENS 1 pt. 6,238
  10. Avatar for Window Group 30. Window Group 1 pt. 6,228
  1. Avatar for Binnie 251. Binnie Lv 1 1 pt. 1,270
  2. Avatar for DNAdoer 252. DNAdoer Lv 1 1 pt. 0
  3. Avatar for jflat06 253. jflat06 Lv 1 1 pt. 0
  4. Avatar for chuebner8053 254. chuebner8053 Lv 1 1 pt. 0
  5. Avatar for Hanna Kim 255. Hanna Kim Lv 1 1 pt. 0
  6. Avatar for roma2907 256. roma2907 Lv 1 1 pt. 0
  7. Avatar for GreekCivilization 257. GreekCivilization Lv 1 1 pt. 0
  8. Avatar for Michael Cleroux 258. Michael Cleroux Lv 1 1 pt. 0
  9. Avatar for Googol30 259. Googol30 Lv 1 1 pt. 0
  10. Avatar for T. Douwes 260. T. Douwes Lv 1 1 pt. 0

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 10% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Disulfide Filter: Yields a bonus of up to 1000 points for 2 or 3 disulfide bonds. More than 3 disulfides will incur penalties.