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1048: 26 Residue Peptide Design

Closed since about 11 years ago

Intermediate Overall Design

Summary

Created
February 05, 2015
Expires
Max points
100
Description

This puzzle is aimed at designing short peptides that fold into stable structures. We encourage the use of multiple disulfide bonds, but discourage GLY residues, which will score especially poorly here. See the puzzle comments for more information about filters. The Baker lab will run folding predictions on your best designs, and the the ones that perform well will be synthesized and further validated for structural stability. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Russian team 21. Russian team 1 pt. 8,349
  2. Avatar for StructuralBiology-CHEM490 22. StructuralBiology-CHEM490 1 pt. 8,309
  3. Avatar for Eὕρηκα! Heureka! 23. Eὕρηκα! Heureka! 1 pt. 8,301
  4. Avatar for FoldIt@Netherlands 24. FoldIt@Netherlands 1 pt. 8,288
  5. Avatar for Deleted group 25. Deleted group pts. 7,434
  6. Avatar for CS3824F14 26. CS3824F14 1 pt. 6,294
  7. Avatar for test_group1 27. test_group1 1 pt. 6,289
  8. Avatar for DSN @ Home 28. DSN @ Home 1 pt. 6,239
  9. Avatar for pROO-TEENS 29. pROO-TEENS 1 pt. 6,238
  10. Avatar for Window Group 30. Window Group 1 pt. 6,228
  1. Avatar for Bautho 31. Bautho Lv 1 57 pts. 9,507
  2. Avatar for hpaege 32. hpaege Lv 1 56 pts. 9,506
  3. Avatar for Skippysk8s 33. Skippysk8s Lv 1 55 pts. 9,495
  4. Avatar for HerobrinesArmy 34. HerobrinesArmy Lv 1 54 pts. 9,489
  5. Avatar for Sissue 35. Sissue Lv 1 53 pts. 9,488
  6. Avatar for frood66 36. frood66 Lv 1 52 pts. 9,485
  7. Avatar for Madde 37. Madde Lv 1 50 pts. 9,476
  8. Avatar for isaksson 38. isaksson Lv 1 49 pts. 9,474
  9. Avatar for BCAA 39. BCAA Lv 1 48 pts. 9,473
  10. Avatar for christioanchauvin 40. christioanchauvin Lv 1 47 pts. 9,471

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 10% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Disulfide Filter: Yields a bonus of up to 1000 points for 2 or 3 disulfide bonds. More than 3 disulfides will incur penalties.